The correct answer is option 1, which states that the 2006 Nobel Prize in Medicine was awarded jointly to Andrew Z. Fire of Stanford University, School of Medicine, and Craig C. Mello of the University of Massachusetts Medical School, Worcester.

Option 2, which states that the prize was awarded to John C. Mather of NASA Centre, Maryland, is incorrect. John C. Mather actually received the Nobel Prize in Physics in 2006, not the Nobel Prize in Medicine.

Option 3, which states that the prize was awarded to Roger D. Koruberg of Stanford University, California, in addition to Andrew Z. Fire and Craig C. Mello, is incorrect. There is no record of Roger D. Koruberg receiving the Nobel Prize in Medicine in 2006.

Option 4, which states that the prize was awarded to John C. Mather, Roger D. Koruberg, and Craig C. Mello, is also incorrect. As mentioned earlier, John C. Mather and Roger D. Koruberg did not receive the Nobel Prize in Medicine in 2006.

Therefore, the correct answer is option 1, as it correctly states that the Nobel Prize in Medicine in 2006 was awarded jointly