“Metastasis” is the process by which

Metastasis is the process by which cancer cells spread from a primary tumour to form new tumours in distant organs, typically by entering and traveling through the blood circulation or the lymphatic system. Studies and reviews state that metastatic tumor cells reach distant organs via blood or lymphatic vessels [1], clinical resources summarize that metastasis occurs when cancer cells break off, enter the bloodstream or lymphatics, and establish secondary growths [2], and patient-oriented explanations note that metastatic cells break away and form new tumours elsewhere in the body. Options 1 and 4 describe drug effects or inhibition, not spread; option 3 describes chromosome attachment during metaphase of mitosis, which is unrelated.

Sources

1. [1] https://www.science.org/doi/10.1126/science.aal3622