The correct answer to the question is option 3, Guwahati. Guwahati hosted the Twelfth South Asian Games in 2016. The South Asian Games is a multi-sport event held among the athletes from South Asian countries. It is organized by the South Asian Olympic Council.

Option 1, Patiala, option 2, Kochi, and option 4, Agartala, are incorrect answers. These cities did not host the Twelfth South Asian Games in 2016.

It is important to note that answering questions about specific events or locations may require up-to-date information, as events and hosting cities can change over time. If there have been changes since the time this question was asked, the correct answer may be different.