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Q114 (IAS/1999) Science & Technology › Basic Science (Physics, Chemistry, Biology) › Genetics and evolution Answer Verified

Which one of the following genetic diseases is sex-linked ?

Result
Your answer: —  ·  Correct: A
Explanation

Royal haemophilia (hemophilia) is an X-linked (sex-linked) disorder; historically called the “royal disease” and classically transmitted as an X‑linked recessive trait, with females typically being carriers and affected males showing the phenotype [1]. By contrast, Tay–Sachs disease and cystic fibrosis are examples of autosomal recessive disorders, which are inherited independent of sex chromosomes and affect males and females equally [2]. Hypertension is generally a multifactorial condition involving polygenic and environmental factors rather than a single sex-linked gene [3]. Therefore, of the options given, Royal haemophilia is the sex-linked disease.

Sources

  1. [1] https://apacwomen.ac.in/learning-resources/zoology/GENETICS.pdf
  2. [2] https://www.sciencedirect.com/topics/immunology-and-microbiology/inheritance
  3. [3] https://www.ncbi.nlm.nih.gov/books/NBK236037/
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Which one of the following is caused by the expression of a recessive gene present on sex chromosome ?

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Statement I: Human beings have 23 pair of chromosomes, one of which is the sex chromosome and the remaining 22 autosomes. The X-linked diseases are related to mutations on a sex chromosome. Statement II: Colour blindness results from a mutation in X-chromosome.