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Q80 (IAS/2021) Science & Technology โ€บ Biotechnology & Health โ€บ Microbiology and antimicrobials Official Key

Consider the following statements : 1. Adenoviruses have single-stranded DNA genomes whereas retroviruses have double-stranded DNA genomes. 2. Common cold is sometime caused by an adenovirus whereas AIDS is caused by a retrovirus. Which of the statements given above is/are correct?

Result
Your answer: โ€”  ยท  Correct: B
Explanation

The correct answer is Option 2.

Statement 1 is incorrect because it inaccurately describes the genomic structures of both viruses. Adenoviruses possess double-stranded DNA (dsDNA) genomes, not single-stranded. Conversely, retroviruses (like HIV) contain single-stranded RNA (ssRNA) genomes, which they convert into DNA using the enzyme reverse transcriptase once inside a host cell; they do not have a double-stranded DNA genome in their virion state.

Statement 2 is correct. Adenoviruses are a well-known cause of respiratory infections, including the common cold, sore throats, and bronchitis. AIDS is caused by the Human Immunodeficiency Virus (HIV), which is a classic example of a retrovirus. Since statement 1 is scientifically inaccurate regarding the genetic material and statement 2 correctly identifies the causative agents of the mentioned diseases, only the second statement holds true.

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Donโ€™t just practise โ€“ reverse-engineer the question. This panel shows where this PYQ came from (books / web), how the examiner broke it into hidden statements, and which nearby micro-concepts you were supposed to learn from it. Treat it like an autopsy of the question: what might have triggered it, which exact lines in the book matter, and what linked ideas you should carry forward to future questions.
Q. Consider the following statements : 1. Adenoviruses have single-stranded DNA genomes whereas retroviruses have double-stranded DNA genomโ€ฆ
At a glance
Origin: Mostly Current Affairs Fairness: Low / Borderline fairness Books / CA: 0/10 ยท 10/10

This question is a classic 'Current Affairs disguised as Static Science'. In 2021, the world was discussing Covishield (Adenovirus vector) vs. mRNA vaccines. UPSC pivoted from the vaccine brand names to the fundamental biology of the vectors used. If a major disease/tech is in the news, master its biological basics (Genome type: DNA vs RNA).

How this question is built

This question can be broken into the following sub-statements. Tap a statement sentence to jump into its detailed analysis.

Statement 1
Adenoviruses have single-stranded DNA genomes.
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"For example, adeno-associated viral (AAV) vectors are single-stranded DNA, whereas [adenovirus] is double-stranded."
Why this source?
  • Explicitly states the genome-type comparison between AAV and adenovirus.
  • Says adenovirus is double-stranded, which directly contradicts the claim that adenoviruses have single-stranded DNA genomes.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
Strength: 5/5
โ€œViruses are microscopic and acellular. Viruses multiply when they enter a living cell. They may infect plants, animals, or bacterial cells and may cause a disease.โ€
Why relevant

States that viruses are acellular entities that multiply only inside living cells, implying they carry some form of genetic material to direct replication.

How to extend

A student could combine this with the external fact that different viruses carry either DNA or RNA genomes and then look up whether adenoviruses are DNA or RNA viruses and whether their DNA is single- or double-stranded.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
Strength: 3/5
โ€œTherefore, a basic event in reproduction is the creation of a DNA copy. Cells use chemical reactions to build copies of their DNA. This creates two copies of the DNA in a reproducing cell, and they will need to be separated from each other. However, keeping one copy of DNA in the original cell and simply pushing the other one out would not work,โ€
Why relevant

Explains DNA copying as a fundamental biological process and treats DNA as the molecule that stores genetic information in reproducing entities.

How to extend

Using this general rule, a student can reason that if adenoviruses rely on host machinery to replicate, identifying their nucleic acid type (DNA vs RNA) and structure (single vs double strand) would determine how replication proceeds.

Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
Strength: 2/5
โ€œinherited. This is explained by the fact that each gene set is present, not as a single long thread of DNA, but as separate independent pieces, each called a chromosome. Thus, each cell will have two copies of each chromosome, one each from the male and female parents. Every germcell will take one chromosome from each pair and these may be of either maternal or paternal origin. When two germ cells combine, they will restore the normal number of chromosomes in the progeny, ensuring the stability of the DNA of the species. Such a mechanism of inheritance explains the results of the Mendel experiments, and is used by all sexually reproducing organisms.โ€
Why relevant

Describes DNA organized into chromosomes in cellular organisms, illustrating that biological genetic material can have defined structural organizations.

How to extend

A student could use this pattern (genetic material has characteristic structures) and external virology references to compare viral genome organizations (e.g., chromosomes vs viral nucleic acid forms) and thereby investigate adenovirus genome strandness.

Statement 2
Retroviruses have double-stranded DNA genomes.
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 1/5
"the only exception to this are retroviruses, which are characterized by the reverse transcription of their viral RNA genome into a linear double-stranded DNA molecule (viral DNA intermediate), and thus the substrate for subsequent viral genome integration into the host genome."
Why this source?
  • Explicitly states retroviruses have an RNA genome that is reverse-transcribed into a linear double-stranded DNA intermediate.
  • Indicates the dsDNA is an intermediate (product of reverse transcription) used for integration, not the native viral genome.
Web source
Presence: 1/5
"Retroviruses replicate through a double-stranded DNA (dsDNA) intermediate and integrate their genomes stably into the host cells' DNA, a"
Why this source?
  • States retroviruses replicate through a double-stranded DNA (dsDNA) intermediate, implying the dsDNA is not the original genomic form.
  • Notes integration of that dsDNA intermediate into host DNA, again distinguishing intermediate from native genome.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
Strength: 4/5
โ€œViruses are microscopic and acellular. Viruses multiply when they enter a living cell. They may infect plants, animals, or bacterial cells and may cause a disease.โ€
Why relevant

Defines viruses as acellular agents that multiply inside living cells, indicating viruses are a distinct class of genetic entities whose genomes can differ from cellular genomes.

How to extend

A student could combine this with external knowledge that viral genomes vary in type (DNA or RNA, single- or double-stranded) to question whether retroviruses necessarily carry DNA genomes.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
Strength: 3/5
โ€œTherefore, a basic event in reproduction is the creation of a DNA copy. Cells use chemical reactions to build copies of their DNA. This creates two copies of the DNA in a reproducing cell, and they will need to be separated from each other. However, keeping one copy of DNA in the original cell and simply pushing the other one out would not work,โ€
Why relevant

Explains that cells create copies of DNA, producing two DNA copies in a reproducing cell โ€” highlighting the common cellular pattern of double-stranded/duplicated DNA during replication.

How to extend

One could contrast this cellular DNA-copying pattern with viral replication strategies (from external sources) to see whether retroviruses follow cellular double-stranded DNA norms or use other molecular mechanisms.

Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
Strength: 2/5
โ€œinherited. This is explained by the fact that each gene set is present, not as a single long thread of DNA, but as separate independent pieces, each called a chromosome. Thus, each cell will have two copies of each chromosome, one each from the male and female parents. Every germcell will take one chromosome from each pair and these may be of either maternal or paternal origin. When two germ cells combine, they will restore the normal number of chromosomes in the progeny, ensuring the stability of the DNA of the species. Such a mechanism of inheritance explains the results of the Mendel experiments, and is used by all sexually reproducing organisms.โ€
Why relevant

Describes genetic material in organisms as organised into chromosomes (separate DNA pieces present in pairs), establishing a pattern of genomic DNA organisation in cells.

How to extend

A student can use this to note that cellular genomes are double-stranded DNA organised into chromosomes and then ask whether viral genomes (retroviruses) share that organisation or differ (requiring outside reference).

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 13: Our Home: Earth, a Unique Life Sustaining Planet > Special cells for reproduction > p. 221
Strength: 2/5
โ€œYou might wonder if both parents pass on their genetic material for making a new organism, won't the child end up with double the amount of instructions? And would not this keep doubling every generation? This does not happen because each parent makes specialised reproductive cells, called gametes. These carry only half of the parent's genetic material . When male and female gametes join, they form a new cell with a complete set of instructionsโ€”half from each parent. Fig. 13.11: Vegetative propagationโ€‰โ€”โ€‰(a) Ginger; (b) Potatoโ€
Why relevant

Mentions parents passing genetic material as halves in gametes, reinforcing the idea that cellular heredity uses DNA as the genetic molecule transmitted in specific forms.

How to extend

From this, a student might infer that 'DNA is the hereditary molecule in cells' and then seek external information on whether retroviruses use DNA or another nucleic acid as their genomic material.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 119
Strength: 2/5
โ€œIf the DNA copying mechanisms were to be less accurate, many of the resultant DNA copies would not be able to work with the cellular apparatus, and would die. So how can the process of making variants be speeded up? Each new variation is made in a DNA copy that already has variations accumulated from previous generations. Thus, two different individuals in a population would have quite different patterns of accumulated variations. Since all of these variations are in living individuals, it is assured that they do not have any really bad effects. Combining variations from two or more individuals would thus create new combinations of variants.โ€
Why relevant

Discusses accumulation and combination of variations in DNA copies across generations, emphasizing that biological information is typically DNA-based in organisms.

How to extend

A student could use this to frame a comparison: since organisms use DNA for heredity, do viruses (specifically retroviruses) also have DNA genomes or do they employ different strategies (to be checked externally)?

Statement 3
Adenoviruses sometimes cause the common cold.
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 4/5
"C are usually acquired in early childhood and cause infections in the upper respiratory, gastrointestinal, and urinary tracts."
Why this source?
  • States that adenoviruses cause infections in the upper respiratory tract.
  • Upper respiratory tract infections include mild respiratory illnesses such as the common cold, so this indicates adenoviruses can sometimes produce common-coldโ€“like infections.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
Strength: 5/5
โ€œDiseases | Causal agent | Site of infection | Symptoms | Preventive measures Diseases spread through the air โ€ข humans: Common cold and influenza; Col2: Virus; Col3: Respiratory tract; Col4: Nasal congestion and discharge, sore throat, fever, cough, body ache; Table 3.1: Some common communicable diseases affecting: Washing hands frequently, not sharing personal items, covering the mouth and nose โ€ข humans: Chickenpox; Col2: Virus; Col3: Respiratory tract, skin; Col4: Mild fever, itchy skin, rashes, blisters; Table 3.1: Some common communicable diseases affecting: Complete isolation of the patient, covering the mouth and nose, vaccination โ€ข humans: Measles; Col2: Virus; Col3: Skin, respiratory tract; Col4: Fever, sore throat, and reddish rashes on the neck, ears and other parts of the skin; Table 3.1: Some common communicable diseases affecting: Isolation of the patient, covering the mouth and nose, maintaining good hygiene, vaccinationโ€
Why relevant

Lists the common cold as a disease whose causal agent is 'Virus' and that infects the respiratory tract.

How to extend

A student could take this general rule (common cold = viral respiratory infection) and check external lists of viruses known to infect the respiratory tract to see if adenoviruses are included among causes of common cold.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
Strength: 4/5
โ€œViruses are microscopic and acellular. Viruses multiply when they enter a living cell. They may infect plants, animals, or bacterial cells and may cause a disease.โ€
Why relevant

Defines viruses as acellular agents that multiply inside living cells and may cause disease in animals, implying that various virus types can cause respiratory illnesses.

How to extend

Use this definition plus knowledge that adenoviruses are a virus family to investigate whether members of that family infect human respiratory cells and can produce cold-like symptoms.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > 3.4.1 How are communicable diseases caused and spread? > p. 32
Strength: 4/5
โ€œAll communicable diseases are caused by pathogens. These pathogens can enter our body through the air we breathe or by consuming contaminated food or water and more. But how do these pathogens spread from one person to another? One common way is through air, when an infected person coughs or sneezes, or through direct contact like shaking hands, or indirectly by sharingโ€
Why relevant

Explains that communicable diseases can spread through the air when an infected person coughs or sneezes โ€” the typical transmission route for many respiratory viruses that cause colds.

How to extend

A student can combine this transmission pattern with external data about adenovirus transmission to assess whether adenoviruses plausibly spread and cause respiratory (cold) illness.

Science-Class VII . NCERT(Revised ed 2025) > Chapter 9: Life Processes in Animals > SCIENCE AND SOCIETY > p. 129
Strength: 3/5
โ€œWhile a lot of the dust is fi ltered out from the inhaled air, often small infectious particles can get through the lungs. For example, during the COVID-19 pandemic, the SARS-CoV-2 virus aff ected the respiratory system, leading to breathing diffi culties and often causing serious lung problems. Fig. 9.8: Human respiratory systemโ€
Why relevant

Gives a concrete example of a virus (SARS-CoV-2) affecting the respiratory system, illustrating that different viruses can cause a spectrum of respiratory diseases.

How to extend

By analogy, a student could look up whether adenoviruses are documented to infect the respiratory tract and produce mild (cold-like) versus severe disease.

Science , class X (NCERT 2025 ed.) > Chapter 5: Life Processes > Do You Know? > p. 90
Strength: 2/5
โ€œSmoking is injurious to health. Lung cancer is one of common causes of deaths in the world. The upper part of respiratory tract is provided with small hair -like structures called cilia. These cilia help to remove germs, dust and other harmful particles from inhaled air. Smoking destroys these hair due to which germs, dust, smoke and other harmful chemicals enter lungs and cause infection, cough and even lung cancer. Within the lungs, the passage divides into smaller and smaller tubes which finally terminate in balloon-like structures which are called alveoli (singularโ€“alveolus). The alveoli provide a surface where the exchange of gases can take place.โ€
Why relevant

Describes how the respiratory tract (cilia, alveoli) defends against inhaled germs and how damage increases susceptibility to infections, relevant to how viruses cause respiratory symptoms.

How to extend

A student could consider host factors affecting susceptibility and then check whether adenovirus infections manifest as upper respiratory (cold) symptoms under normal or predisposed conditions.

Statement 4
AIDS is caused by a retrovirus.
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 4/5
"A serious concern with these vectors is biosafety because the vector is derived from a virus causing AIDS. However, recently modified vectors with more deletions from the HIV-1 genome, the use of heterologous envelopes, and the expression"
Why this source?
  • Discusses lentiviral vectors and directly states biosafety concern because โ€œthe vector is derived from a virus causing AIDS.โ€
  • Refers to the HIV-1 genome in the same context, linking the AIDS-causing virus to HIV-1 and lentiviral (vector) systems.
Web source
Presence: 3/5
"Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans."
Why this source?
  • Mentions HIV-1 repeatedly in the context of vaccination efforts, identifying HIV-1 as the virus of interest in AIDS-related research.
  • Shows that HIV-1 is treated as the causative agent targeted by vaccines, supporting the link between AIDS and HIV-1.
Web source
Presence: 3/5
"Our studies support a mechanism of AIDS virus infection that initially involves the specific interaction of the AIDS virus with T4 molecules on the cell surface"
Why this source?
  • Refers to the โ€˜AIDS virusโ€™ and describes its specific interaction with T4 molecules, identifying a viral cause for AIDS.
  • Provides direct wording that an identifiable virus (the โ€˜AIDS virusโ€™) is responsible for infection processes relevant to AIDS.

Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 80
Strength: 5/5
โ€œAIDS (Acquired Immuno Defciency Syndrome) is a disease of the immune system caused by the human immunodefciency virus (HIV). HIV slowly attacks and destroys the immune system, the bodyโ€
Why relevant

Explicitly states AIDS is caused by the human immunodeficiency virus (HIV), establishing the etiologic agent is a virus.

How to extend

A student could note HIV is a virus and then check external virology references to see whether HIV falls into the retrovirus group.

Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 81
Strength: 4/5
โ€œdefence against infection. It leads to afected person to a variety of other infectious diseases and certain malignancies that eventually cause death. AIDS is the fnal stage of HIV infection, during which time fatal infections and cancers arise. AIDS was frst reported in 1981 by investigators in New York and California (USA). HIV is transmitted by direct transfer of body fuids, such as blood and blood products, semen, and other genital secretions, or breast milk, from an infected person to an uninfected person. Te main cellular target of HIV is a class of white blood cells critical to the immune system known as helper T cells.โ€
Why relevant

Describes HIV's mode of action (slowly attacks/destroys the immune system and targets helper T cells), which is consistent with persistent viral infections that integrate into immune cells.

How to extend

A student could use this pattern (virus targeting immune cells) plus basic virology sources to investigate whether such behaviour is characteristic of retroviruses and whether HIV shares those properties.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.3 (d) Reproductive Health > p. 125
Strength: 4/5
โ€œWe must also consider the possible health consequences of having sex. We have discussed in Class IX that diseases can be transmitted from person to person in a variety of ways. Since the sexual act is a very intimate connection of bodies, it is not surprising that many diseases can be sexually transmitted. These include bacterial infections such as gonorrhoea and syphilis, and viral infections such as warts and HIV-AIDS. Is it possible to prevent the transmission of such diseases during the sexual act? Using a covering, called a condom, for the penis during sex helps to prevent transmission of many of these infections to some extent.โ€
Why relevant

Classifies HIV-AIDS among viral infections in the context of sexually transmitted diseases, reinforcing that the causative agent is a virus rather than a bacterium or protozoan.

How to extend

Knowing HIV is a virus, the student can consult standard virology texts or reference sources to determine the subclassification (e.g., retrovirus).

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > 3.4 Diseases: What Are the Causes and Types? > p. 32
Strength: 3/5
โ€œA disease is a condition that affects the normal working of the body or mind. It can happen when one or more organs or organ systems stop functioning properly. Some diseases are caused by germs like bacteria, viruses, fungi, worms, or even by protozoa (single-celled organisms). These disease-causing organisms are called pathogens. Other diseases may result from poor nutrition or an unhealthy lifestyle. Some diseases last for a short time, while others can continue for a long time and need regular treatment or care. Diseases can be grouped into two major types based on their causes and how they spread:โ€
Why relevant

Defines pathogens to include viruses and notes diseases can be caused by viruses, giving a general rule that viral identification matters for determining disease class.

How to extend

A student could apply this general rule to treat the claim 'AIDS is caused by a retrovirus' as a specific viral-classification question and look up HIV's virus family externally.

Contemporary World Politics, Textbook in political science for Class XII (NCERT 2025 ed.) > Chapter 5: Security in the Contemporary World > Security in the Contemporary World 75 > p. 75
Strength: 2/5
โ€œBy 2003, an estimated 4 crore people were infected with HIV-AIDS worldwide, two-thirds of them in Africa and half of the rest in South Asia. In North America and other industrialised countries, new drug therapies dramatically lowered the death rate from HIV-AIDS in the late 1990s. But these treatments were too expensive to help poor regions like Africa where it has proved to be a major factor in driving the region backward into deeper poverty. Other new and poorly understood diseases such as Corona, ebola virus, hantavirus, and hepatitis C have emerged, w h i l e o l d d i s e a s e s l i k e tuberculosis, malaria, dengue fever and cholera have mutated into drug resistant forms that are difficult to treat.โ€
Why relevant

Mentions other named viruses (e.g., ebola) in the context of emerging diseases, showing these texts distinguish diseases by specific virus names and types.

How to extend

A student could infer that since the textbook distinguishes viruses by name/type, they should consult authoritative virology classification resources to see whether HIV is categorized as a retrovirus.

Pattern takeaway: UPSC rarely asks 'Which vaccine uses Adenovirus?' (too trivial). They ask 'What is the biological nature of an Adenovirus?' They test the *fundamental science* underlying the *current news*.
How you should have studied
  1. [THE VERDICT]: Sitter disguised as a Bouncer. While 'Adenovirus genome' sounds technical, the error in Statement 1 regarding Retroviruses (which have RNA, not DNA) is standard NCERT Class 12 Biology.
  2. [THE CONCEPTUAL TRIGGER]: The 2020-21 COVID-19 Vaccine race. Covishield/Sputnik used Adenoviral vectors; Pfizer/Moderna used mRNA. This forced a comparison of viral genomes.
  3. [THE HORIZONTAL EXPANSION]: Memorize the 'Big 5' Viral Genomes: 1. Coronavirus (ssRNA), 2. Influenza (Segmented ssRNA), 3. HIV/Retrovirus (ssRNA + Reverse Transcriptase), 4. Adenovirus (dsDNA), 5. Bacteriophage (usually dsDNA).
  4. [THE STRATEGIC METACOGNITION]: When reading about a 'Viral Vector Vaccine', do not stop at the definition. Ask: 'Is the vector DNA or RNA?' and 'Does it integrate into my genome?' This depth defines the difference between a generalist and a serious aspirant.
Concept hooks from this question
๐Ÿ“Œ Adjacent topic to master
S1
๐Ÿ‘‰ Virus basic properties and host-dependent replication
๐Ÿ’ก The insight

Viruses are acellular and replicate only within living host cells, which frames questions about their genomes and replication strategies.

High-yield for prelims and mains: basic viral biology is frequently tested and underpins topics in disease ecology, public health and molecular biology. Mastering this helps differentiate viruses from cellular organisms and reason about how viral genome type affects replication and control measures.

๐Ÿ“š Reading List :
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
๐Ÿ”— Anchor: "Adenoviruses have single-stranded DNA genomes."
๐Ÿ“Œ Adjacent topic to master
S1
๐Ÿ‘‰ Chromosomal organization and ploidy in cellular organisms
๐Ÿ’ก The insight

Cells package genetic material into distinct chromosomes and maintain haploid/diploid gene sets, providing a basis to contrast cellular genomes with viral genomes.

Important for genetics and reproduction questions; helps compare organismal DNA organization with viral genomes and supports reasoning on inheritance, genome size and complexity in exam questions that ask for differences between cellular life and viruses.

๐Ÿ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
  • Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > 8.2.3 How do these Traits get Expressed? > p. 131
๐Ÿ”— Anchor: "Adenoviruses have single-stranded DNA genomes."
๐Ÿ“Œ Adjacent topic to master
S1
๐Ÿ‘‰ Imperfect DNA copying and generation of genetic variation
๐Ÿ’ก The insight

DNA replication is not perfectly accurate, producing variations that accumulate across generations and affect heredity and evolution.

Useful for questions on mutation, evolution, and comparative genome dynamics; understanding replication fidelity helps evaluate how different genome types (viral or cellular) influence variation and adaptability.

๐Ÿ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 119
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
๐Ÿ”— Anchor: "Adenoviruses have single-stranded DNA genomes."
๐Ÿ“Œ Adjacent topic to master
S3
๐Ÿ‘‰ Viruses as primary agents of the common cold
๐Ÿ’ก The insight

The common cold is caused by viral agents rather than bacteria.

High-yield for public health and biology questions: understanding that viruses (not bacteria) are the dominant cause of common cold informs prevention, treatment (limited role for antibiotics), and vaccination policy debates. Connects to topics on pathogen types, infectious disease control, and clinical management questions in UPSC mains and interviews.

๐Ÿ“š Reading List :
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
๐Ÿ”— Anchor: "Adenoviruses sometimes cause the common cold."
๐Ÿ“Œ Adjacent topic to master
S3
๐Ÿ‘‰ Airborne transmission of respiratory pathogens
๐Ÿ’ก The insight

Respiratory infections commonly spread through the air via coughing and sneezing.

Essential for framing responses on disease spread, containment measures, and public health advisories. Links to epidemiology, infection control, and disaster/health management topics; useful for answering questions on prevention strategies and community health interventions.

๐Ÿ“š Reading List :
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > 3.4.1 How are communicable diseases caused and spread? > p. 32
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
๐Ÿ”— Anchor: "Adenoviruses sometimes cause the common cold."
๐Ÿ“Œ Adjacent topic to master
S3
๐Ÿ‘‰ Respiratory tract as the site and symptom profile of common cold
๐Ÿ’ก The insight

Common cold infects the respiratory tract and produces symptoms like nasal congestion, sore throat, cough and fever.

Crucial for clinical-scenario and public-health questions where identification of disease by site and symptoms is tested. Helps integrate physiology of respiratory system with disease impact and prevention measures in policy-related answers.

๐Ÿ“š Reading List :
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
  • Science , class X (NCERT 2025 ed.) > Chapter 5: Life Processes > Do You Know? > p. 90
๐Ÿ”— Anchor: "Adenoviruses sometimes cause the common cold."
๐Ÿ“Œ Adjacent topic to master
S4
๐Ÿ‘‰ HIV as the causative agent of AIDS
๐Ÿ’ก The insight

AIDS is described as being caused by the human immunodeficiency virus (HIV), so understanding the causal link between HIV and AIDS is fundamental.

High-yield for questions on infectious diseases and public health; links to immunology (helper T cell depletion), clinical outcomes, and policy responses. Mastering this helps answer questions on disease etiology, classification, and health interventions.

๐Ÿ“š Reading List :
  • Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 80
  • Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 81
๐Ÿ”— Anchor: "AIDS is caused by a retrovirus."
๐ŸŒ‘ The Hidden Trap

Since they tested DNA vs RNA viruses, the next logical sibling is 'Acellular' pathogens. Expect a question comparing **Viroids** (free RNA, no protein coat, e.g., Potato Spindle Tuber) vs **Prions** (misfolded proteins, no genetic material, e.g., Mad Cow Disease/Creutzfeldt-Jakob).

โšก Elimination Cheat Code

Etymological Hack: Look at the word 'Retrovirus' in Statement 1. 'Retro' implies 'Reverse' (Reverse Transcription). This process is only needed to convert RNA to DNA. If the virus already had a 'double-stranded DNA genome' (as the statement claims), it wouldn't be called a Retrovirus. This internal contradiction eliminates Statement 1 immediately.

๐Ÿ”— Mains Connection

Link this to **GS3 Biotechnology (Gene Therapy)**. Retroviruses are used as vectors in gene therapy because they integrate into the host genome (permanent cure potential but cancer risk). Adenoviruses stay episomal (temporary effect, safer). This distinction is crucial for Mains answers on CRISPR/Cas9 delivery systems.

โœ“ Thank you! We'll review this.

SIMILAR QUESTIONS

CDS-I ยท 2017 ยท Q5 Relevance score: -0.20

Most viruses that infect plants possess

IAS ยท 2004 ยท Q141 Relevance score: -0.59

Consider the following statements: 1. Femur is the longest bone in the human body. 2. Cholera is a disease caused by bacteria. 3. โ€˜Athleteโ€™s footโ€™ is a disease caused by virus. Which of the statements given above are correct?

NDA-I ยท 2018 ยท Q19 Relevance score: -0.85

AIDS is caused by a virus whose genetic material is

IAS ยท 2004 ยท Q12 Relevance score: -1.07

Consider the following statements: 1. Toothless mammals such as pangolins are not found in India. 2. Gibbon is the only ape found in India. Which of the statements given above is are correct?

NDA-I ยท 2016 ยท Q31 Relevance score: -1.37

_ Which of the following statements about DNA is/are correct ? 1. DNA is the hereditary material of all living organisms. . 2. All segments of DNA code for synthesis of proteins. 3. Nuclear DNA is double helical with two nucleotide chains which run anti-parallel. 4. DNA is also found in mitochondria. Select the correct answer using the code given below: