Question map
Consider the following statements : 1. Adenoviruses have single-stranded DNA genomes whereas retroviruses have double-stranded DNA genomes. 2. Common cold is sometime caused by an adenovirus whereas AIDS is caused by a retrovirus. Which of the statements given above is/are correct?
Explanation
The correct answer is Option 2.
Statement 1 is incorrect because it inaccurately describes the genomic structures of both viruses. Adenoviruses possess double-stranded DNA (dsDNA) genomes, not single-stranded. Conversely, retroviruses (like HIV) contain single-stranded RNA (ssRNA) genomes, which they convert into DNA using the enzyme reverse transcriptase once inside a host cell; they do not have a double-stranded DNA genome in their virion state.
Statement 2 is correct. Adenoviruses are a well-known cause of respiratory infections, including the common cold, sore throats, and bronchitis. AIDS is caused by the Human Immunodeficiency Virus (HIV), which is a classic example of a retrovirus. Since statement 1 is scientifically inaccurate regarding the genetic material and statement 2 correctly identifies the causative agents of the mentioned diseases, only the second statement holds true.
PROVENANCE & STUDY PATTERN
Full viewThis question is a classic 'Current Affairs disguised as Static Science'. In 2021, the world was discussing Covishield (Adenovirus vector) vs. mRNA vaccines. UPSC pivoted from the vaccine brand names to the fundamental biology of the vectors used. If a major disease/tech is in the news, master its biological basics (Genome type: DNA vs RNA).
This question can be broken into the following sub-statements. Tap a statement sentence to jump into its detailed analysis.
- Explicitly states the genome-type comparison between AAV and adenovirus.
- Says adenovirus is double-stranded, which directly contradicts the claim that adenoviruses have single-stranded DNA genomes.
States that viruses are acellular entities that multiply only inside living cells, implying they carry some form of genetic material to direct replication.
A student could combine this with the external fact that different viruses carry either DNA or RNA genomes and then look up whether adenoviruses are DNA or RNA viruses and whether their DNA is single- or double-stranded.
Explains DNA copying as a fundamental biological process and treats DNA as the molecule that stores genetic information in reproducing entities.
Using this general rule, a student can reason that if adenoviruses rely on host machinery to replicate, identifying their nucleic acid type (DNA vs RNA) and structure (single vs double strand) would determine how replication proceeds.
Describes DNA organized into chromosomes in cellular organisms, illustrating that biological genetic material can have defined structural organizations.
A student could use this pattern (genetic material has characteristic structures) and external virology references to compare viral genome organizations (e.g., chromosomes vs viral nucleic acid forms) and thereby investigate adenovirus genome strandness.
- Explicitly states retroviruses have an RNA genome that is reverse-transcribed into a linear double-stranded DNA intermediate.
- Indicates the dsDNA is an intermediate (product of reverse transcription) used for integration, not the native viral genome.
- States retroviruses replicate through a double-stranded DNA (dsDNA) intermediate, implying the dsDNA is not the original genomic form.
- Notes integration of that dsDNA intermediate into host DNA, again distinguishing intermediate from native genome.
Defines viruses as acellular agents that multiply inside living cells, indicating viruses are a distinct class of genetic entities whose genomes can differ from cellular genomes.
A student could combine this with external knowledge that viral genomes vary in type (DNA or RNA, single- or double-stranded) to question whether retroviruses necessarily carry DNA genomes.
Explains that cells create copies of DNA, producing two DNA copies in a reproducing cell โ highlighting the common cellular pattern of double-stranded/duplicated DNA during replication.
One could contrast this cellular DNA-copying pattern with viral replication strategies (from external sources) to see whether retroviruses follow cellular double-stranded DNA norms or use other molecular mechanisms.
Describes genetic material in organisms as organised into chromosomes (separate DNA pieces present in pairs), establishing a pattern of genomic DNA organisation in cells.
A student can use this to note that cellular genomes are double-stranded DNA organised into chromosomes and then ask whether viral genomes (retroviruses) share that organisation or differ (requiring outside reference).
Mentions parents passing genetic material as halves in gametes, reinforcing the idea that cellular heredity uses DNA as the genetic molecule transmitted in specific forms.
From this, a student might infer that 'DNA is the hereditary molecule in cells' and then seek external information on whether retroviruses use DNA or another nucleic acid as their genomic material.
Discusses accumulation and combination of variations in DNA copies across generations, emphasizing that biological information is typically DNA-based in organisms.
A student could use this to frame a comparison: since organisms use DNA for heredity, do viruses (specifically retroviruses) also have DNA genomes or do they employ different strategies (to be checked externally)?
- States that adenoviruses cause infections in the upper respiratory tract.
- Upper respiratory tract infections include mild respiratory illnesses such as the common cold, so this indicates adenoviruses can sometimes produce common-coldโlike infections.
Lists the common cold as a disease whose causal agent is 'Virus' and that infects the respiratory tract.
A student could take this general rule (common cold = viral respiratory infection) and check external lists of viruses known to infect the respiratory tract to see if adenoviruses are included among causes of common cold.
Defines viruses as acellular agents that multiply inside living cells and may cause disease in animals, implying that various virus types can cause respiratory illnesses.
Use this definition plus knowledge that adenoviruses are a virus family to investigate whether members of that family infect human respiratory cells and can produce cold-like symptoms.
Explains that communicable diseases can spread through the air when an infected person coughs or sneezes โ the typical transmission route for many respiratory viruses that cause colds.
A student can combine this transmission pattern with external data about adenovirus transmission to assess whether adenoviruses plausibly spread and cause respiratory (cold) illness.
Gives a concrete example of a virus (SARS-CoV-2) affecting the respiratory system, illustrating that different viruses can cause a spectrum of respiratory diseases.
By analogy, a student could look up whether adenoviruses are documented to infect the respiratory tract and produce mild (cold-like) versus severe disease.
Describes how the respiratory tract (cilia, alveoli) defends against inhaled germs and how damage increases susceptibility to infections, relevant to how viruses cause respiratory symptoms.
A student could consider host factors affecting susceptibility and then check whether adenovirus infections manifest as upper respiratory (cold) symptoms under normal or predisposed conditions.
- Discusses lentiviral vectors and directly states biosafety concern because โthe vector is derived from a virus causing AIDS.โ
- Refers to the HIV-1 genome in the same context, linking the AIDS-causing virus to HIV-1 and lentiviral (vector) systems.
- Mentions HIV-1 repeatedly in the context of vaccination efforts, identifying HIV-1 as the virus of interest in AIDS-related research.
- Shows that HIV-1 is treated as the causative agent targeted by vaccines, supporting the link between AIDS and HIV-1.
- Refers to the โAIDS virusโ and describes its specific interaction with T4 molecules, identifying a viral cause for AIDS.
- Provides direct wording that an identifiable virus (the โAIDS virusโ) is responsible for infection processes relevant to AIDS.
Explicitly states AIDS is caused by the human immunodeficiency virus (HIV), establishing the etiologic agent is a virus.
A student could note HIV is a virus and then check external virology references to see whether HIV falls into the retrovirus group.
Describes HIV's mode of action (slowly attacks/destroys the immune system and targets helper T cells), which is consistent with persistent viral infections that integrate into immune cells.
A student could use this pattern (virus targeting immune cells) plus basic virology sources to investigate whether such behaviour is characteristic of retroviruses and whether HIV shares those properties.
Classifies HIV-AIDS among viral infections in the context of sexually transmitted diseases, reinforcing that the causative agent is a virus rather than a bacterium or protozoan.
Knowing HIV is a virus, the student can consult standard virology texts or reference sources to determine the subclassification (e.g., retrovirus).
Defines pathogens to include viruses and notes diseases can be caused by viruses, giving a general rule that viral identification matters for determining disease class.
A student could apply this general rule to treat the claim 'AIDS is caused by a retrovirus' as a specific viral-classification question and look up HIV's virus family externally.
Mentions other named viruses (e.g., ebola) in the context of emerging diseases, showing these texts distinguish diseases by specific virus names and types.
A student could infer that since the textbook distinguishes viruses by name/type, they should consult authoritative virology classification resources to see whether HIV is categorized as a retrovirus.
- [THE VERDICT]: Sitter disguised as a Bouncer. While 'Adenovirus genome' sounds technical, the error in Statement 1 regarding Retroviruses (which have RNA, not DNA) is standard NCERT Class 12 Biology.
- [THE CONCEPTUAL TRIGGER]: The 2020-21 COVID-19 Vaccine race. Covishield/Sputnik used Adenoviral vectors; Pfizer/Moderna used mRNA. This forced a comparison of viral genomes.
- [THE HORIZONTAL EXPANSION]: Memorize the 'Big 5' Viral Genomes: 1. Coronavirus (ssRNA), 2. Influenza (Segmented ssRNA), 3. HIV/Retrovirus (ssRNA + Reverse Transcriptase), 4. Adenovirus (dsDNA), 5. Bacteriophage (usually dsDNA).
- [THE STRATEGIC METACOGNITION]: When reading about a 'Viral Vector Vaccine', do not stop at the definition. Ask: 'Is the vector DNA or RNA?' and 'Does it integrate into my genome?' This depth defines the difference between a generalist and a serious aspirant.
Viruses are acellular and replicate only within living host cells, which frames questions about their genomes and replication strategies.
High-yield for prelims and mains: basic viral biology is frequently tested and underpins topics in disease ecology, public health and molecular biology. Mastering this helps differentiate viruses from cellular organisms and reason about how viral genome type affects replication and control measures.
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
Cells package genetic material into distinct chromosomes and maintain haploid/diploid gene sets, providing a basis to contrast cellular genomes with viral genomes.
Important for genetics and reproduction questions; helps compare organismal DNA organization with viral genomes and supports reasoning on inheritance, genome size and complexity in exam questions that ask for differences between cellular life and viruses.
- Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
- Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > 8.2.3 How do these Traits get Expressed? > p. 131
DNA replication is not perfectly accurate, producing variations that accumulate across generations and affect heredity and evolution.
Useful for questions on mutation, evolution, and comparative genome dynamics; understanding replication fidelity helps evaluate how different genome types (viral or cellular) influence variation and adaptability.
- Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 119
- Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
The common cold is caused by viral agents rather than bacteria.
High-yield for public health and biology questions: understanding that viruses (not bacteria) are the dominant cause of common cold informs prevention, treatment (limited role for antibiotics), and vaccination policy debates. Connects to topics on pathogen types, infectious disease control, and clinical management questions in UPSC mains and interviews.
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Ever heard of ... > p. 17
Respiratory infections commonly spread through the air via coughing and sneezing.
Essential for framing responses on disease spread, containment measures, and public health advisories. Links to epidemiology, infection control, and disaster/health management topics; useful for answering questions on prevention strategies and community health interventions.
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > 3.4.1 How are communicable diseases caused and spread? > p. 32
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
Common cold infects the respiratory tract and produces symptoms like nasal congestion, sore throat, cough and fever.
Crucial for clinical-scenario and public-health questions where identification of disease by site and symptoms is tested. Helps integrate physiology of respiratory system with disease impact and prevention measures in policy-related answers.
- Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > Activity 3.4: Let us find out > p. 33
- Science , class X (NCERT 2025 ed.) > Chapter 5: Life Processes > Do You Know? > p. 90
AIDS is described as being caused by the human immunodeficiency virus (HIV), so understanding the causal link between HIV and AIDS is fundamental.
High-yield for questions on infectious diseases and public health; links to immunology (helper T cell depletion), clinical outcomes, and policy responses. Mastering this helps answer questions on disease etiology, classification, and health interventions.
- Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 80
- Environment and Ecology, Majid Hussain (Access publishing 3rd ed.) > Chapter 8: Natural Hazards and Disaster Management > AIDs/HIVs > p. 81
Since they tested DNA vs RNA viruses, the next logical sibling is 'Acellular' pathogens. Expect a question comparing **Viroids** (free RNA, no protein coat, e.g., Potato Spindle Tuber) vs **Prions** (misfolded proteins, no genetic material, e.g., Mad Cow Disease/Creutzfeldt-Jakob).
Etymological Hack: Look at the word 'Retrovirus' in Statement 1. 'Retro' implies 'Reverse' (Reverse Transcription). This process is only needed to convert RNA to DNA. If the virus already had a 'double-stranded DNA genome' (as the statement claims), it wouldn't be called a Retrovirus. This internal contradiction eliminates Statement 1 immediately.
Link this to **GS3 Biotechnology (Gene Therapy)**. Retroviruses are used as vectors in gene therapy because they integrate into the host genome (permanent cure potential but cancer risk). Adenoviruses stay episomal (temporary effect, safer). This distinction is crucial for Mains answers on CRISPR/Cas9 delivery systems.