Diabetes is the most common disorder associated with :

Diabetes mellitus is a chronic metabolic disorder primarily associated with the pancreas. The pancreas is a gland that performs both exocrine and endocrine functions. Its endocrine component consists of the islets of Langerhans, which contain beta cells that produce the hormone insulin.

Insulin is essential for regulating blood glucose levels by allowing cells to absorb sugar from the bloodstream. Diabetes occurs when the pancreas either does not produce enough insulin (Type 1) or the body cannot effectively use the insulin it produces (Type 2). While chronic diabetes can eventually lead to complications in the kidneys (nephropathy), liver, and heart, the primary organ responsible for the onset of the disorder is the pancreas.