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Q37
(IAS/2005)
Science & Technology › Biotechnology & Health › Human genetics and disorders
Answer Verified
Assertion (A) : The person with diabetes insipidus feels thirsty. Reason (R) : A person with diabetes insipidus suffers from excess secretion of vasopressin.
Result
Your answer:
—
·
Correct:
C
Explanation
The chief clinical features of diabetes insipidus (DI) include passage of large volumes of dilute urine with compensatory thirst and excessive fluid intake (polydipsia), so the assertion that a person with DI feels thirsty is correct [3]. However, DI is caused by either inadequate production/secretion of vasopressin (central/AVP deficiency) or by renal resistance to vasopressin (nephrogenic/AVP resistance), not by excess vasopressin secretion. Thus the reason given (excess vasopressin) is incorrect; the disorder reflects deficiency or resistance of vasopressin action rather than hormone excess [3]. Therefore A is true and R is false.
Sources
- [1] https://www.niddk.nih.gov/health-information/kidney-disease/diabetes-insipidus
- [3] https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1479764/full
- [2] https://www.ncbi.nlm.nih.gov/books/NBK470458/
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