The question asks about the first large research reactor in India that uses U-233 as fuel. In order to understand the options and select the correct answer, let`s analyze each one:

1. ZERLINA: There is no information available about ZERLINA being a research reactor in India that uses U-233 as fuel.

2. PURNIMA: There is also no information about PURNIMA being a research reactor in India that uses U-233 as fuel.

3. DHRUVA: DHRUVA is a research reactor located in Mumbai, India. However, it does not use U-233 as fuel but instead uses enriched uranium.

4. KAMINI: KAMINI is correctly identified as the first large research reactor in India that uses U-233 as fuel. It is a unique reactor located in Kalpakkam, Tamil Nadu. It is a fast breeder reactor that uses U-233, which is derived from thorium, as its fuel.

Therefore, option 4, KAMINI, is the correct answer to the question.

Note: It`s important to mention that U-233 is a fissile material and KAMINI, being a research reactor, is used for experimental purposes only and not for power