The gastrointestinal hormones namely secretin and chole- cystokinin secreted by duodenal epithelium activate respectively which organs to discharge their secretions ?

Secretin and cholecystokinin (CCK) are key gastrointestinal hormones secreted by the duodenal epithelium in response to chyme. Secretin primarily targets the pancreas, stimulating the secretion of bicarbonate-rich pancreatic fluid to neutralize gastric acid [2]. It also inhibits gastric acid secretion and motility [2]. Cholecystokinin (CCK) acts on the gallbladder, causing it to contract and release stored bile into the small intestine for fat emulsification. Additionally, CCK stimulates the pancreatic acinar cells to release digestive enzymes. While both hormones have secondary effects on the stomach, such as slowing gastric emptying to ensure efficient digestion, their primary discharge-related targets for secretion are the pancreas (for bicarbonate and enzymes) and the gallbladder (for bile) [2]. Therefore, they activate the pancreas and gallbladder respectively to discharge their secretions.

Sources

1. [1] https://www.ncbi.nlm.nih.gov/books/NBK537116/
2. [2] https://www.sciencedirect.com/science/article/pii/S1016847824001511