Lysosome is formed from which of the following cell organelles?

Lysosomes are membrane-bound organelles that originate from the Golgi apparatus (also known as Golgi bodies). Within the endomembrane system, proteins and enzymes synthesized in the rough endoplasmic reticulum are transported via vesicles to the Golgi apparatus [1]. The Golgi apparatus acts as a sorting and distribution center, where these molecular components are modified and packaged [1]. Specifically, the trans-Golgi network directs molecular traffic to form lysosomes, which contain various hydrolases responsible for macromolecule degradation [1]. While the endoplasmic reticulum provides the initial proteins and lipids, the actual formation and budding of the lysosomal vesicles occur at the Golgi complex [2]. This process ensures that digestive enzymes are safely sequestered within a single lipid bilayer to prevent cellular self-digestion . Therefore, the Golgi bodies are the primary organelle responsible for the biogenesis of lysosomes.

Sources

1. [1] https://www.ncbi.nlm.nih.gov/books/NBK9838/
2. [2] https://www.nature.com/scitable/topicpage/endoplasmic-reticulum-golgi-apparatus-and-lysosomes-14053361/