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Q93 (IAS/2019) Science & Technology β€Ί Biotechnology & Health β€Ί Genetic engineering basics Official Key

With reference to the recent developments in science, which one of the following statements is not correct?

Result
Your answer: β€”  Β·  Correct: A
Explanation

The correct answer is option A. While artificial gene synthesis processes can be scaled up to create functional genes, multi-gene circuits[1] or even entire synthetic chromosomes or genomes[1], and methods exist for cloning segments of natural chromosomes and programmably assembling them into synthetic chromosomes[2], these processes work with DNA from the same or compatible species. Creating functional chromosomes by joining segments from cells of **different species** is not a standard achievable practice, as cross-species chromosomal assembly faces significant incompatibility issues.

The other options are correct: Functional genes and synthetic chromosomes can be created in laboratories[1] (Option B). DNA amplification allows multiplication of DNA pieces in test tubes into millions of copies, most commonly using the polymerase chain reaction (PCR) system[3] (Option C). In tissue culture, cells can be cultured in vitro (in glass vessels) where they undergo division and development[5] (Option D).

Sources
  1. [1] https://en.wikipedia.org/wiki/Artificial_gene_synthesis
  2. [2] https://pmc.ncbi.nlm.nih.gov/articles/PMC10733283/
  3. [3] https://openknowledge.fao.org/server/api/core/bitstreams/44b59eaf-ec5d-4773-98ee-a20d02b4b604/content
  4. [4] https://openknowledge.fao.org/server/api/core/bitstreams/44b59eaf-ec5d-4773-98ee-a20d02b4b604/content
  5. [5] https://openknowledge.fao.org/server/api/core/bitstreams/44b59eaf-ec5d-4773-98ee-a20d02b4b604/content
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Each bar shows the % of students who chose that option. Green bar = correct answer, blue outline = your choice.
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Q. With reference to the recent developments in science, which one of the following statements is not correct? [A] Functional chromosomes c…
At a glance
Origin: Mostly Current Affairs Fairness: Low / Borderline fairness Books / CA: 0/10 Β· 7.5/10

This is a 'Wolf in Sheep's Clothing'. It masquerades as a high-tech Current Affairs question, but Options B, C, and D are actually standard static concepts found in NCERT Class 12 Biology (Biotechnology unit). You solve this by validating the basics you know (PCR, Tissue Culture), not by researching obscure synthetic biology papers.

How this question is built

This question can be broken into the following sub-statements. Tap a statement sentence to jump into its detailed analysis.

Statement 1
In recent developments in science, have researchers been able to create functional chromosomes by joining segments of DNA taken from cells of different species?
Origin: Weak / unclear Fairness: Borderline / guessy
Indirect textbook clues
Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
Strength: 5/5
β€œinherited. This is explained by the fact that each gene set is present, not as a single long thread of DNA, but as separate independent pieces, each called a chromosome. Thus, each cell will have two copies of each chromosome, one each from the male and female parents. Every germcell will take one chromosome from each pair and these may be of either maternal or paternal origin. When two germ cells combine, they will restore the normal number of chromosomes in the progeny, ensuring the stability of the DNA of the species. Such a mechanism of inheritance explains the results of the Mendel experiments, and is used by all sexually reproducing organisms.”
Why relevant

Defines chromosomes as separate independent pieces of DNA and notes cells carry two copies (one from each parent), highlighting DNA is organised in modular units.

How to extend

A student could infer that because chromosomes are discrete units, one might test whether joining segments from different sources could form a complete, functioning chromosome and then check compatibility across species.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 120
Strength: 4/5
β€œreproduction incorporates such a process of combining DNA from two different individuals during reproduction. But this creates a major difficulty. If each new generation is to be the combination of the DNA copies from two pre-existing individuals, then each new generation will end up having twice the amount of DNA that the previous generation had. This is likely to mess up the control of the cellular apparatus by the DNA. How many ways can we think of for solving this difficulty? We have seen earlier that as organisms become more complex, the specialisation of tissue increases. One solution that many multi-cellular organisms have found for the problem mentioned above is to have special lineages of cells in specialised organs in which only half the number of chromosomes and half the amount of DNA as compared to the nonreproductive body cells.”
Why relevant

Explains that reproduction involves combining DNA from two individuals and that maintaining correct DNA amount and control is critical.

How to extend

Use the rule that genome dosage and control matters to assess whether chimeric chromosomes from different species would function without disrupting cellular control mechanisms.

Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > 8.2.3 How do these Traits get Expressed? > p. 131
Strength: 4/5
β€œHow does the mechanism of heredity work? Cellular DNA is the information source for making proteins in the cell. A section of DNA that provides information for one protein is called the gene for that protein. How do proteins control the characteristics that we are discussing here? Let us take the example of tallness as a characteristic. We know that plants have hormones that can trigger growth. Plant height can thus depend on the amount of a particular plant hormone. The amount of the plant hormone made will depend on the efficiency of the process for making it. Consider now an enzyme that is important for this process.”
Why relevant

Describes a gene as a DNA section encoding a protein, emphasising functional modularity at the gene level.

How to extend

From gene modularity, a student could reason that assembling segments that contain intact genes might produce specific protein functions, but must consider regulatory context and species-specific expression.

Statement 2
In recent developments in science, can pieces of artificial functional DNA be synthesized or created in laboratories?
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"a primer containing about 20 nucleotides and complementary to a sequence near the end of sequenced DNA is synthesized, and is then used for sequencing the next few hundred"
Why this source?
  • Explicitly states short DNA oligonucleotides (primers) are synthesized in the laboratory.
  • Shows that synthetic DNA pieces (β‰ˆ20 nucleotides) are produced for sequencing and experimental use, supporting that artificial DNA can be made.
Web source
Presence: 4/5
"microprojectile bombardment A procedure for modifying cells by shooting DNA-coated metal (tungsten or gold) particles into them."
Why this source?
  • Describes laboratory methods that use DNA introduced into cells (DNA-coated particles), indicating practical handling and use of exogenous DNA in lab settings.
  • Implies that DNA material is prepared and applied experimentally to create genetic modifications in cells.
Web source
Presence: 3/5
"This can include specific agricultural, horticultural or other work techniques as well as genetic manipulation of the organism to alter its dissemination abilities. These techniques are not only important for research under contained conditions, e.g. in laboratories and greenhouses,"
Why this source?
  • Refers to genetic manipulation of organisms carried out in laboratories and greenhouses, placing DNA modification/engineering squarely in lab research.
  • Connects laboratory containment and research practices with techniques that alter organism genomes, implying creation or use of artificial genetic material.

Indian Economy, Nitin Singhania .(ed 2nd 2021-22) > Chapter 9: Agriculture > GENETICALLY MODIFIED (GM) CROPS > p. 301
Strength: 5/5
β€œβ€’ According to WHO, Genetically Modified Organisms (GMO) are the plants, animals or microorganisms in which the hereditary material (DNA) is altered in a manner that does not happen normally by mating or potentially regular recombination. It is also known as modern biotechnology/gene technology.β€’ When genetic modification of a plant is performed, foreign gene (transgene) or gene of some other organism is artificially inserted into the plant's own genes. This is gene modification.”
Why relevant

Defines genetically modified organisms as ones whose hereditary material (DNA) is altered in a manner that does not occur by normal mating, and says foreign genes are artificially inserted into a plant's genes.

How to extend

A student could combine this with basic knowledge that inserting genes requires creating or handling DNA sequences in the lab, suggesting laboratory creation/manipulation of functional DNA segments.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
Strength: 4/5
β€œTherefore, a basic event in reproduction is the creation of a DNA copy. Cells use chemical reactions to build copies of their DNA. This creates two copies of the DNA in a reproducing cell, and they will need to be separated from each other. However, keeping one copy of DNA in the original cell and simply pushing the other one out would not work,”
Why relevant

States that cells use chemical reactions to build copies of their DNA, framing DNA as a molecule assembled by chemistry.

How to extend

Knowing DNA is a chemical polymer, a student could infer that chemical or biochemical synthesis methods might be used in labs to assemble DNA pieces.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
Strength: 3/5
β€œbecause the copy pushed out would not have any organised cellular structure for maintaining life processes. Therefore, DNA copying is accompanied by the creation of an additional cellular apparatus, and then the DNA copies separate, each with its own cellular apparatus. Effectively, a cell divides to give rise to two cells. These two cells are of course similar, but are they likely to be absolutely identical? The answer to this question will depend on how accurately the copying reactions involved occur. No bio-chemical reaction is absolutely reliable. Therefore, it is only to be expected that the process of copying the DNA will have some variations each time.”
Why relevant

Notes that DNA copying is a biochemical process prone to small inaccuracies that create variations.

How to extend

A student might extend this to the idea that deliberate changes (rather than accidental ones) can be introduced using laboratory techniques to create variant DNA sequences with functional effects.

Environment, Shankar IAS Acedemy .(ed 10th) > Chapter 16: Conservation Efforts > Goals: > p. 249
Strength: 4/5
β€œβ€’ Deliver DNA barcoding technology for 5 million species. β€’ Develop the informatics platform and analytical protocols required for the development of a DNA barcode reference library. β€’ Establish a core facility to provide sequencing and informatics support. β€’ Complete the census of all multicellular species. β€’ Establish a global biosurveillance program. β€’ Construct a 'library of life' by preserving DNA extracts from all species.”
Why relevant

Describes efforts to build a DNA barcode reference library and facilities for sequencing and preserving DNA extracts.

How to extend

Given widespread sequencing and preservation infrastructure, a student could reason labs have the data and tools needed to design and then synthesize tested DNA sequences.

Statement 3
In recent developments in science, can a piece of DNA extracted from an animal cell be made to replicate outside a living cell under laboratory conditions?
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"DNA amplification Multiplication of a piece of DNA in a test-tube into many thousands of millions of copies. The most commonly used process is the polymerase chain reaction (PCR) system, but other systems are being developed, including ligase chain reaction (LCR), nucleic acids sequence-dependent amplification, and the Q-Ξ² system."
Why this source?
  • Defines DNA amplification as multiplication of a piece of DNA in a test-tube, directly stating in vitro replication is possible.
  • Names PCR and other cell-free systems as methods to make many millions of copies outside living cells.
Web source
Presence: 3/5
"site-directed mutagenesis The introduction of base changes – mutations – into a piece of DNA at a specific site, using recombinant DNA methods."
Why this source?
  • Describes site-directed mutagenesis as changes introduced into a piece of DNA using recombinant DNA methods, indicating manipulation of isolated DNA outside cells.
  • Shows molecular techniques exist to alter and work with DNA fragments in laboratory (supporting feasibility of ex vivo handling and replication workflows).

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
Strength: 4/5
β€œTherefore, a basic event in reproduction is the creation of a DNA copy. Cells use chemical reactions to build copies of their DNA. This creates two copies of the DNA in a reproducing cell, and they will need to be separated from each other. However, keeping one copy of DNA in the original cell and simply pushing the other one out would not work,”
Why relevant

States that DNA copying is a basic event in reproduction and that cells use chemical reactions to build copies of their DNA.

How to extend

A student can take the rule that DNA replication depends on chemical reactions and ask whether those reactions (enzymes, substrates, conditions) can be reproduced in a lab environment outside a whole living cell.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
Strength: 5/5
β€œbecause the copy pushed out would not have any organised cellular structure for maintaining life processes. Therefore, DNA copying is accompanied by the creation of an additional cellular apparatus, and then the DNA copies separate, each with its own cellular apparatus. Effectively, a cell divides to give rise to two cells. These two cells are of course similar, but are they likely to be absolutely identical? The answer to this question will depend on how accurately the copying reactions involved occur. No bio-chemical reaction is absolutely reliable. Therefore, it is only to be expected that the process of copying the DNA will have some variations each time.”
Why relevant

Explicitly notes that DNA copying is accompanied by creation/maintenance of an organised cellular apparatus and that simply having a DNA copy outside would lack that apparatus.

How to extend

One could use this to reason that replication outside cells would require substituting or reconstructing the necessary cellular apparatus or its functions in vitro to enable copying.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 119
Strength: 4/5
β€œThe creation of two new cells from one involves copying of the DNA as well as of the cellular apparatus. The DNA copying mechanism, as we have noted, cannot be absolutely accurate, and the resultant errors are a source of variations in populations of organisms. Every individual organism cannot be protected by variations, but in a population, variations are useful for ensuring the survival of the species. It would therefore make sense if organisms came up with reproductive modes that allowed more and more variation to be generated. While DNA-copying mechanisms are not absolutely accurate, they are precise enough to make the generation of variation a fairly slow process.”
Why relevant

Emphasises that DNA copying mechanisms operate inside cells and that copying is not perfectly accurate (errors arise from biochemical reactions).

How to extend

A student could use this to consider whether isolated DNA in lab conditions would need the same biochemical machinery and whether fidelity of copying might differ outside cellular contexts.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > What you have learnt > p. 126
Strength: 4/5
β€œβ€’ n Reproduction, unlike other life processes, is not essential to maintain the life of an individual organism.β€’ n Reproduction involves creation of a DNA copy and additional cellular apparatus by the cell involved in the process.β€’ n Various organisms use different modes of reproduction depending on their body design.β€’ n In fission, many bacteria and protozoa simply divide into two or more daughter cells.β€’ n Organisms such as hydra can regenerate if they are broken into pieces.”
Why relevant

Summarises that reproduction involves creation of a DNA copy and additional cellular apparatus by the cell involved in the process.

How to extend

This summary supports asking if laboratory methods must provide both the copying chemistry and some form of supporting apparatus (enzymatic systems, controlled environment) to replicate DNA outside cells.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.2.3 Regeneration > p. 116
Strength: 3/5
β€œMany fully differentiated organisms have the ability to give rise to new individual organisms from their body parts. That is, if the individual is somehow cut or broken up into many pieces, many of these pieces grow into separate individuals. For example, simple animals like Hydra and Planaria can be cut into any number of pieces and each piece grows into a complete organism. This is known as regeneration (see Fig. 7.3). Regeneration is carried out by specialised cells. These cells proliferate and make large numbers of cells. From this mass of cells, different cells undergo changes to become various cell types and tissues.”
Why relevant

Describes regeneration where specialised cells proliferate and generate many cellsβ€”showing that DNA copying is tied to cellular proliferation performed by specialised cell machinery.

How to extend

A student could infer that DNA replication in vitro would need to mimic specialised cellular proliferation machinery or provide the key components those cells use.

Statement 4
In recent developments in science, can cells taken from plants and animals be induced to undergo cell division in laboratory petri dishes (in vitro)?
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"cytokinin Plant growth regulators (hormones) characterized as substances that induce cell division and cell differentiation (e.g., BA, kinetin, and 2-iP). In tissue culture, these substances are associated with enhanced callus and shoot development."
Why this source?
  • Explicitly states plant growth regulators (cytokinins) are substances that induce cell division and differentiation.
  • Links those regulators to tissue culture outcomes (callus and shoot development), showing induction of division in vitro.
Web source
Presence: 4/5
"in vitro (L. for β€œin glass”) Living in test tubes, outside the organism or in an artificial environment, typically in glass vessels in which cultured cells, tissues, organs or whole plants may reside."
Why this source?
  • Defines 'in vitro' as living in test tubes or artificial vessels where cultured cells, tissues or whole plants reside.
  • Establishes the laboratory context (glass vessels/petri-dish-like environments) for inducing cell behavior outside the organism.
Web source
Presence: 4/5
"totipotency Having the potentiality of forming all the types of cells in the body. The property of somatic cells to be induced to undergo regeneration."
Why this source?
  • Defines totipotency as the property of somatic cells to be induced to undergo regeneration.
  • Implies that cells taken from organisms can be stimulated (in experimental settings) to divide and regenerate different cell types.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > Tissue culture > p. 118
Strength: 5/5
β€œIn tissue culture, new plants are grown by removing tissue or separating cells from the growing tip of a plant. The cells are then placed in an artificial medium where they divide rapidly to form a small group of cells or callus. The callus is transferred to another medium containing hormones for growth and differentiation. The plantlets are then placed in the soil so that they can grow into mature plants. Using tissue culture, many plants can be grown from one parent in disease-free conditions. This technique is commonly used for ornamental plants.”
Why relevant

Describes tissue culture where cells removed from a plant are placed in an artificial medium and 'divide rapidly to form a small group of cells or callus.'

How to extend

A student could infer that providing artificial medium and hormones can induce plant cells removed from a plant to divide in laboratory conditions (in vitro) and test this by attempting plant tissue culture in a sterile medium with growth regulators.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.2.3 Regeneration > p. 116
Strength: 4/5
β€œMany fully differentiated organisms have the ability to give rise to new individual organisms from their body parts. That is, if the individual is somehow cut or broken up into many pieces, many of these pieces grow into separate individuals. For example, simple animals like Hydra and Planaria can be cut into any number of pieces and each piece grows into a complete organism. This is known as regeneration (see Fig. 7.3). Regeneration is carried out by specialised cells. These cells proliferate and make large numbers of cells. From this mass of cells, different cells undergo changes to become various cell types and tissues.”
Why relevant

Explains regeneration: specialised cells proliferate and make large numbers of cells, which then differentiate into tissues.

How to extend

One could extend this pattern to hypothesise that certain differentiated animal cells (or specialised regenerative cells) can be stimulated to proliferate outside the organism if given appropriate signals or environment and then design cell culture experiments to test proliferation.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.2.1 Fission > p. 115
Strength: 3/5
β€œFor unicellular organisms, cell division, or fission, leads to the creation of new individuals. Many different patterns of fission have been observed. Many bacteria and protozoa simply split into two equal halves during cell division. In organisms such as Amoeba, the splitting of the two cells during division can take place in any plane.”
Why relevant

Notes that unicellular organisms undergo cell division (fission) naturally, showing that cells inherently possess division mechanisms.

How to extend

Combine this basic rule with the idea that if single cells divide naturally, providing suitable lab conditions (nutrients, sterile environment) might allow isolated cells to divide in vitro, so one could attempt to culture isolated single cells to observe division.

Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 120
Strength: 3/5
β€œThis is achieved by a process of cell division called meiosis. Thus, when these germ-cells from two individuals combine during sexual reproduction to form a new individual, it results in reestablishment of the number of chromosomes and the DNA content in the new generation. If the zygote is to grow and develop into an organism which has highly specialised tissues and organs, then it has to have sufficient stores of energy for doing this. In very simple organisms, it is seen that the two germ-cells are not very different from one another, or may even be similar. But as the body designs become more complex, the germ-cells also specialise.”
Why relevant

Describes cell division processes (meiosis) in germ cells as a defined cellular mechanism for producing new cells.

How to extend

A student can infer that since cell division is a definable cellular program (mitosis/meiosis), it may be triggered or supported in isolated cells under controlled lab conditions (e.g., by supplying energy/nutrients or appropriate cues) and plan experiments to culture germ or somatic cells to observe division.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > Activity 2.2: Let us study a cell (Teacher demonstration activity) > p. 11
Strength: 2/5
β€œCompare it with Fig. 2.3c.β€’ z What similarities do you find in Fig. 2.3c and Fig. 2.3d? You will observe nearly rectangular structures under the microscope. These are the cells of the onion peel, which are closely arranged without any space between them. Try to observe the peels of the leaves of different plants around you. You will find that all plants are made up of cells. What do you think the body of an animal is made of?”
Why relevant

Shows that plant cells (onion peel) are readily observable under microscope and exist as intact units, implying they can be isolated and studied.

How to extend

A learner might extend this by isolating visible plant cells and attempting to culture them on media to see whether they undergo division in vitro.

Pattern takeaway: UPSC frequently tests 'established' science (10-20 years old) under the label of 'Recent Developments'. If an option describes a standard textbook process (like PCR or Cell Culture), treat it as a known fact. The 'Not Correct' statement is often an exaggeration that violates a fundamental biological barrier (like species compatibility).
How you should have studied
  1. [THE VERDICT]: Sitter disguised as a Bouncer. Solvable purely via NCERT Class 12 Biology (Biotechnology Principles).
  2. [THE CONCEPTUAL TRIGGER]: Biotechnology & Applications. Specifically: PCR (Polymerase Chain Reaction) and Tissue Culture.
  3. [THE HORIZONTAL EXPANSION]: 1. PCR steps (Denaturation, Annealing, Extension). 2. Totipotency (Plant cells) vs Pluripotency (Stem cells). 3. Somatic Hybridization (Protoplast fusion, e.g., Pomato). 4. Three-parent baby (Mitochondrial replacement). 5. CAR-T Cell Therapy (modifying T-cells).
  4. [THE STRATEGIC METACOGNITION]: When a question asks 'Which is NOT correct' about 'Recent Developments', look for the options that are definitely TRUE based on static textbooks. Option C is PCR. Option D is Tissue Culture. Option B is basic Primer Synthesis. By elimination, A is the outlier.
Concept hooks from this question
πŸ“Œ Adjacent topic to master
S1
πŸ‘‰ Chromosomes as discrete hereditary units
πŸ’‘ The insight

Chromosomes are separate, independent pieces of DNA that carry genes and are inherited as units.

High-yield for questions on inheritance and Mendelian genetics; connects concepts of genes, karyotypes, and how traits are transmitted across generations. Mastery helps answer questions about chromosomal basis of traits and chromosomal abnormalities.

πŸ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
πŸ”— Anchor: "In recent developments in science, have researchers been able to create function..."
πŸ“Œ Adjacent topic to master
S1
πŸ‘‰ Haploid germ cells and maintenance of chromosome number
πŸ’‘ The insight

Sexual reproduction uses specialised germ cells with half the number of chromosomes so that fusion of two gametes restores the species' normal chromosome count.

Critical for understanding meiosis, fertilisation, ploidy, and why sexual reproduction prevents genome doubling each generation. Useful for questions on reproductive biology, life cycles, and genetic stability.

πŸ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 120
  • Science , class X (NCERT 2025 ed.) > Chapter 8: Heredity > separate traits, shape and colour of seeds Figure 8.5 > p. 132
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.3 Reproduction in Human Beings > p. 122
πŸ”— Anchor: "In recent developments in science, have researchers been able to create function..."
πŸ“Œ Adjacent topic to master
S1
πŸ‘‰ DNA replication fidelity as the source of genetic variation
πŸ’‘ The insight

DNA copying is not perfectly accurate; occasional errors during replication generate variations within populations.

Central to topics on mutation, evolution, and heredity; explains origin of variation that natural selection acts on and underpins questions on evolutionary mechanisms and genetic disorders.

πŸ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.1 Why the Sexual Mode of Reproduction? > p. 119
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
πŸ”— Anchor: "In recent developments in science, have researchers been able to create function..."
πŸ“Œ Adjacent topic to master
S2
πŸ‘‰ DNA replication accuracy and variation
πŸ’‘ The insight

DNA copying is a chemical process that produces near-identical copies but introduces small variations that affect heredity and diversity.

High-yield: explains mutation, inheritance patterns and the origin of biological variation; links to evolution, breeding and genetic disorders. Mastering this helps answer questions on causes of variation, fidelity of replication and implications for population genetics.

πŸ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 114
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > What you have learnt > p. 126
πŸ”— Anchor: "In recent developments in science, can pieces of artificial functional DNA be sy..."
πŸ“Œ Adjacent topic to master
S2
πŸ‘‰ Genetic modification and transgenes
πŸ’‘ The insight

Hereditary material can be altered by artificially inserting a foreign gene (transgene) into an organism's genome.

High-yield: central to biotechnology and GM crop policy debates; connects to agriculture, biosafety, regulation and socio-economic impacts. Useful for questions on methods, benefits, risks and governance of gene technology.

πŸ“š Reading List :
  • Indian Economy, Nitin Singhania .(ed 2nd 2021-22) > Chapter 9: Agriculture > GENETICALLY MODIFIED (GM) CROPS > p. 301
πŸ”— Anchor: "In recent developments in science, can pieces of artificial functional DNA be sy..."
πŸ“Œ Adjacent topic to master
S2
πŸ‘‰ DNA barcoding and biobanking
πŸ’‘ The insight

Techniques exist to sequence, catalogue and preserve DNA extracts for species identification and biosurveillance.

High-yield: relevant to biodiversity assessment, conservation strategy and forensic identification; connects to large-scale databases, biosurveillance infrastructure and national biodiversity missions. Enables questions on technological capability and conservation policy.

πŸ“š Reading List :
  • Environment, Shankar IAS Acedemy .(ed 10th) > Chapter 16: Conservation Efforts > Goals: > p. 249
πŸ”— Anchor: "In recent developments in science, can pieces of artificial functional DNA be sy..."
πŸ“Œ Adjacent topic to master
S3
πŸ‘‰ DNA replication is a cellular biochemical process
πŸ’‘ The insight

DNA copying is carried out by biochemical reactions that operate within the cell.

High-yield for questions on cell biology and biotechnology basics: distinguishes in vivo cellular replication from laboratory techniques and frames limits of simple extrapolation. Connects to topics on molecular biology methods, ethical debates, and biosciences policy in GS papers.

πŸ“š Reading List :
  • Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.1 DO ORGANISMS CREATE EXACT COPIES OF THEMSEL THEMSELVES? > p. 113
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 2: The Invisible Living World: Beyond Our Naked Eye > A step further > p. 13
πŸ”— Anchor: "In recent developments in science, can a piece of DNA extracted from an animal c..."
πŸŒ‘ The Hidden Trap

Somatic Hybridization (Protoplast Fusion). While creating a 'functional chromosome' from different species is false (Option A), fusing entire cells from different species (e.g., Potato + Tomato) is possible but often results in sterile or unstable hybrids. UPSC loves testing the limits of 'mixing' species.

⚑ Elimination Cheat Code

The 'Complexity vs. Compatibility' Heuristic. Options B, C, and D describe manipulating *components* (DNA pieces, single cells). Option A describes creating a highly complex *structure* (Chromosome) from *incompatible sources* (different species). In biology, 'different species' usually implies a barrier. Nature hates chimeras at the chromosomal level. Bet against the option that claims to easily overcome species barriers.

πŸ”— Mains Connection

GS-3 Internal Security & Disaster Management: Link Option B (Artificial DNA) to 'Biosecurity' and 'Dual-use Research'. If artificial DNA can be created in labs, it raises the threat of engineered pathogens (Bioterrorism) and the need for the Biological Weapons Convention (BWC).

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SIMILAR QUESTIONS

IAS Β· 2002 Β· Q7 Relevance score: 2.14

With reference to the latest developments in stem cell research, consider the following statements: 1. The only source of human stem cells are the embryos at blastocyst stage 2. The stem cells can be derived a without causing destruction to blastocysts 3. The stem cells can regenerate themselves in vitro virtually forever 4. Indian research centres also created a few cell lines which can be developed into many types of tissues Which of these statements are correct?

NDA-I Β· 2011 Β· Q47 Relevance score: 0.54

Which one among the following statements regarding cell is not correct ?

NDA-II Β· 2010 Β· Q35 Relevance score: -0.18

Statement I: Human beings have 23 pair of chromosomes, one of which is the sex chromosome and the remaining 22 autosomes. The X-linked diseases are related to mutations on a sex chromosome. Statement II: Colour blindness results from a mutation in X-chromosome.

CDS-I Β· 2021 Β· Q120 Relevance score: -0.45

Which of the following statements about β€˜fission’ is correct ? 1. It is related with the creation of new individuals by means of cell division in unicellular organism. 2. It is related with the transformation of heavier nuclei into smaller nuclei. 3. It is related with the creation of a heavier nuclei by means of combining two higher nuclei. Select the correct answer using the code given below :

CDS-I Β· 2015 Β· Q8 Relevance score: -0.50

Which one among the following statements is correct ?