The correct answer for the first successful heart transplantation is option 2, C.N. Barnard. While options 1, 3, and 4 are not correct in this case, it is important to understand the significance of C.N. Barnard in the field of heart transplantation. Dr. Christiaan Barnard, a South African surgeon, successfully performed the world`s first human-to-human heart transplant in 1967. The operation took place at Groote Schuur Hospital in Cape Town, South Africa. This groundbreaking procedure revolutionized the field of transplantation and opened new possibilities for treating heart disease. Dr. Barnard`s pioneering work paved the way for advancements in cardiac surgery, leading to the development of more refined techniques and improved patient outcomes. His achievement remains significant in medical history as a testament to the progress made in saving lives through organ transplantation.