The correct answer is option-4, "None of the above." Based on the given information, it is clear that Ms. X will not be able to go to work on the day because NH-2, the route she takes to work, will be closed for repair. However, the answer does not specify whether she has any alternative means of transportation or if she can work remotely. Therefore, option-1 is not entirely accurate.

Similarly, the answer does not provide any information about the possibility of rescheduling the meeting. While missing the meeting may mean missing a big opportunity for Ms. X, it does not exclude the possibility of rescheduling it to another day or another time. Therefore, option-2 is not necessarily true.

While it is implied that missing the meeting may result in missing a big opportunity for Ms. X, it is not explicitly stated in the given information. It could be possible that she is able to catch up on the missed opportunity in some other way. Therefore, option-3 cannot be deemed as a definite outcome.

In conclusion, based on the information provided, none of the given options can be wholly considered as following.