The question asks for the first Viceroy of the Portuguese in the East. Let`s analyze each option:

Option 1: Albuquerque - This is not the correct answer. Although Albuquerque was a prominent Portuguese commander in the East, he did not serve as the first Viceroy.

Option 2: Joa de Castro - This is not the correct answer. Joa de Castro was a Portuguese nobleman and military commander, but he also did not serve as the first Viceroy.

Option 3: Francisco de Almedia - This is the correct answer. Francisco de Almedia was appointed as the first Viceroy of the Portuguese in the East in 1505. He played a significant role in expanding Portuguese influence and control in the region.

Option 4: Nuno da Cunha - This is not the correct answer. Nuno da Cunha was a later Viceroy in the East, serving from 1529 to 1538.

Therefore, the correct answer is option 3, Francisco de Almedia, as he was the first Viceroy of the Portuguese in the East.