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The ozone hole in the atmosphere is primarily caused by the presence of chlorofluorocarbons (CFCs), which are the main component in aerosol sprays, refrigerants, and foam-blowing agents. CFCs release chlorine and bromine atoms when they reach the stratosphere, where the ozone layer is located. These chlorine and bromine atoms then break apart ozone molecules, leading to a depletion of the ozone layer.
Option 1, oxygen, is a natural component of the atmosphere and does not directly cause the ozone hole.
Option 2, hydrogen, is also a natural component and does not contribute to ozone depletion.
Option 4, radioactive waste, is not related to the formation or depletion of the ozone hole.
Therefore, the correct answer is option 3, chlorofluorocarbon.