Question map
Which one of the following is the mechanism of action of oral contraceptive pills?
Explanation
Oral contraceptive pills (OCPs) primarily function by altering the body's hormonal balance to prevent pregnancy [1]. The most common formulations are combined oral contraceptives containing both estrogen and progestin [2]. These hormones work by providing negative feedback to the hypothalamus and pituitary gland, which inhibits the release of an egg from the ovaries, a process known as ovulation [1]. By preventing ovulation, there is no egg available in the fallopian tube for fertilization by sperm [4]. Additionally, these pills thicken the cervical mucus to create a physical barrier that inhibits sperm from reaching the uterus and may also alter the uterine lining to prevent implantation [3]. Unlike spermicides, they do not kill sperm, nor do they function by killing eggs or zygotes; their primary mechanism is the suppression of the ovulatory cycle.
Sources
- [1] Science , class X (NCERT 2025 ed.) > Chapter 7: How do Organisms Reproduce? > 7.3.3 (d) Reproductive Health > p. 125
- [2] https://www.ncbi.nlm.nih.gov/books/NBK283/
- [4] https://opa.hhs.gov/reproductive-health/preventing-pregnancy-contraception
- [3] https://www.sciencedirect.com/science/article/abs/pii/S0002937899701201