Fructose is a natural sweetener, not an artificial sweetener. It is a type of sugar that is naturally found in fruits and honey. Fructose is commonly used as a sweetening agent in processed foods and beverages, as it is sweeter than regular table sugar. Unlike artificial sweeteners, which are chemically synthesized, fructose is derived from natural sources. Option 2, Saccharin, option 3, Sucralose, and option 4, Aspartame, are all artificial sweeteners. Saccharin is a sweetener that was discovered in the late 19th century and is commonly used in diet sodas and other low-calorie products. Sucralose is a newer artificial sweetener that is made from sugar and is commonly marketed under the brand name Splenda. Aspartame is another popular artificial sweetener commonly found in diet beverages and sugar-free products.