Option 1 states that penicillin resistant bacteria can store this antibiotic in vacuole. This statement is incorrect. Penicillin resistant bacteria do not store penicillin in vacuoles. Instead, they have mechanisms to prevent the antibiotic from entering the bacterial cell or to actively pump it out once it has entered.

Option 2 states that penicillin resistant bacteria can degrade penicillin using an enzyme called beta-lactamase. This statement is correct. Beta-lactamase is an enzyme produced by some bacteria that can break down the beta-lactam ring present in penicillin, rendering it ineffective.

Option 3 states that penicillin resistant bacteria can degrade penicillin using an enzyme called lactic acid dehydrogenase. This statement is incorrect. Lactic acid dehydrogenase is not involved in the resistance to penicillin. It is an enzyme involved in the metabolism of lactic acid.

Option 4 states that penicillin is not absorbed by bacteria, and therefore most bacteria are resistant to it. This statement is correct. Penicillin is not easily absorbed by bacteria, and therefore, many bacteria have developed resistance mechanisms to counter its effects.