Option 1: Vitamin B2, also known as riboflavin, is not the correct answer. Deficiency of vitamin B2 can cause symptoms like cracked lips, inflammation of the mouth and tongue, and skin rash, but it does not cause Beri Beri.

Option 2: The correct answer is vitamin B1, also known as thiamine. Beri Beri is caused by a deficiency of this vitamin. Symptoms of Beri Beri include muscle weakness, difficulty walking, decreased sensation in the hands and feet, and heart problems.

Option 3: Vitamin B12 is not the correct answer. Deficiency of vitamin B12 can cause a different condition called pernicious anemia, which affects the production of red blood cells.

Option 4: Vitamin E is not the correct answer. Deficiency of vitamin E can lead to neurological problems and muscle weakness, but it does not cause Beri Beri.

In conclusion, the correct answer is option 2, vitamin B1 deficiency leads to the disease Beri Beri.