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The underlined word in the sentence is "widespread". To determine the opposite meaning, we need to look at the options provided.
Option 1 is "endemic". Endemic refers to a disease that is constantly present in a particular population or region, which is similar to "widespread". Therefore, option 1 is not the opposite of "widespread".
Option 2 is "pervasive". Pervasive means that something is spread throughout an area or group. Again, this is similar to "widespread" and not the opposite.
Option 3 is "common". While "common" could be considered the opposite of "rare", it does not necessarily convey the opposite meaning of "widespread".
Option 4 is "rare". This is the correct answer. "Rare" means that something is not common or not occurring often, which is the opposite meaning of "widespread".
Therefore, the correct answer is option 4.