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The correct answer is option 2: Variola virus.
Option 1: Adenovirus - Adenovirus is a common viral infection that can cause respiratory infections, conjunctivitis, and gastrointestinal issues. However, it is not responsible for smallpox.
Option 3: Aichi virus - Aichi virus is a type of virus that can cause mild gastrointestinal symptoms, such as diarrhea. It is not associated with smallpox.
Option 4: Coxsackie virus - Coxsackie virus is a type of virus that can cause a variety of diseases, including hand, foot, and mouth disease. It is not responsible for smallpox.
Smallpox is caused by the Variola virus, which is highly contagious and has been responsible for devastating outbreaks in the past. Smallpox is characterized by a high fever, rash, and eventually, the formation of pustules on the skin. However, due to successful vaccination efforts, smallpox has been eradicated and no longer exists in the natural world.