Option 1 states that lipases are insoluble in water. Lipases are enzymes that break down fats (lipids) in the human body. Enzymes are usually proteins, and most of them are water-soluble. However, lipases are a special type of enzyme that are insoluble in water. This property allows lipases to efficiently interact with and break down lipid molecules, which are also insoluble in water. Lipases are produced in the pancreas and are important for the digestion and absorption of dietary fats. Once released into the small intestine, lipases break down the triglycerides in fats into smaller molecules called fatty acids and glycerol. These smaller molecules can then be absorbed by the body for energy production and other functions. The insolubility of lipases in water helps them be more effective in breaking down fats in the digestive process. Therefore, option 1 is correct.