The Council of Scientific and Industrial Research (CSIR) is headed by the Prime Minister of India, thus making Option 3 the correct answer. This means that whoever is the current Prime Minister would hold this position. However, this is not the same for the other options. In Option 1 and 2, the President and Vice-President of India, respectively, are mentioned. But neither of these positions leads the CSIR. Option 4 suggests that the Union Minister of Science and Technology is the President of CSIR, which is also incorrect as their role is different, with a more focused responsibility on science and technology policy. Thus, only the Prime Minister of India, as stated in Option 3, holds the position of President in CSIR.