Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine ?

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Q: 21 (IAS/2010)
Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine ?
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question_subject: 

Science

question_exam: 

IAS

stats: 

0,56,57,56,21,15,21

keywords: 

{'effective malaria vaccine': [0, 0, 1, 0], 'malarial vaccine': [0, 0, 1, 0], 'malaria': [5, 0, 2, 1], 'malarial parasite': [0, 0, 0, 2], 'plasmodium': [1, 0, 0, 1], 'vaccines': [0, 0, 0, 1], 'immunity': [0, 0, 2, 4], 'chloroquine': [0, 0, 1, 0], 'widespread resistance': [0, 0, 1, 0], 'natural infection': [0, 0, 1, 0]}