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Q23 (IAS/2015) Science & Technology › Biotechnology & Health › Biopharmaceuticals and nanomedicine Official Key

With reference to the use of nanotechnology in health sector, which of the following statements is/are correct? 1. Targeted drug delivery is made possible by nanotechnology. 2. Nanotechnology can largely contribute to gene therapy. Select the correct answer using the code given below.

Result
Your answer:  ·  Correct: C
Explanation

The correct answer is option C because both statements are correct.

**Statement 1 is correct:** Nanotechnology has revolutionized the field of drug delivery by providing an effective and targeted delivery of drugs, minimizing side effects, and increasing the therapeutic efficacy of drugs.[1] The application of nanotechnology in drug delivery involves the use of nanoparticles that are designed to carry drugs and deliver them to the desired site of action.[2] Nanoparticles with a size of 1–100 nm are unique since they can pass cell membranes and cause characteristic reactions within cells, affecting both the cell structures and organelles.[3]

**Statement 2 is correct:** Gene therapy, combined with nanotechnology, holds great potential as an innovative approach to tackling numerous severe and untreatable illnesses, namely cancer.[4] Using nanotechnology that enabled mRNA-based COVID-19 vaccines, a new approach to gene therapy may improve how physicians treat inherited forms of blindness.[5] This demonstrates that nanotechnology can indeed contribute largely to gene therapy applications.

Therefore, both statements 1 and 2 are correct, making option C the right answer.

Sources
  1. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10536529/
  2. [2] https://pmc.ncbi.nlm.nih.gov/articles/PMC10536529/
  3. [3] https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2025.1639506/full
  4. [4] https://www.sciencedirect.com/science/article/abs/pii/S1773224724007524
  5. [5] https://news.ohsu.edu/2023/01/11/nanotechnology-may-improve-gene-therapy-for-blindness
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Each bar shows the % of students who chose that option. Green bar = correct answer, blue outline = your choice.
Community Performance
Out of everyone who attempted this question.
67%
got it right
PROVENANCE & STUDY PATTERN
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Q. With reference to the use of nanotechnology in health sector, which of the following statements is/are correct? 1. Targeted drug delivery…
At a glance
Origin: Mostly Current Affairs Fairness: Low / Borderline fairness Books / CA: 0/10 · 10/10

This is a classic 'Applications of Emerging Tech' question. It rewards general awareness over rote memorization. In Science & Tech, if a technology is broadly transformative (like Nanotech or AI), its potential applications in major sectors like Health are almost always 'True' unless the statement implies exclusivity or violates basic physics.

How this question is built

This question can be broken into the following sub-statements. Tap a statement sentence to jump into its detailed analysis.

Statement 1
Does the use of nanotechnology in the health sector enable targeted drug delivery?
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"Nanotechnology has revolutionized the field of drug delivery by providing an effective and targeted delivery of drugs, minimizing side effects, and increasing the therapeutic efficacy of drugs."
Why this source?
  • Directly states nanotechnology enables effective, targeted delivery of drugs.
  • Links targeted delivery with reduced side effects and increased therapeutic efficacy, supporting the statement.
Web source
Presence: 4/5
"Targeted drug delivery system Nanoparticles Enhanced permeability and retention Active targeting Controlled release Theranostics Stimuli-responsive"
Why this source?
  • Explicitly lists 'Targeted drug delivery system' and related mechanisms (active targeting, EPR, controlled release).
  • Positions targeted delivery as a central keyword and focus of nanocarrier research, reinforcing the claim.
Web source
Presence: 4/5
"NPs and other nanostructures with a size of 1–100 nm are unique since they can pass cell membranes and cause characteristic reactions within cells, affecting both the cell structures and organelles."
Why this source?
  • Notes nanostructures (1–100 nm) can pass cell membranes and act within cells, a mechanism enabling delivery to specific sites.
  • Highlights intrinsic functions of nanomaterials that make them essential in biomedical applications, implying targeted delivery capability.

Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 62
Strength: 5/5
“The salient features of the modified drug policy (1986) as announced on 15 September, 1994 are: • 1. Abolition of Industrial Licensing for all bulk drugs, their intermediates and formulations except five bulk drugs of the public sector.• 2. Foreign investment up to 51% will be automatically permitted in the case of bulk drugs, their intermediares and their formulations.• 3. Automatic approval for foreign technology agreements shall be given in case of all bulk drugs, their intermediares and formulations, except those produced by the use of recombinant DNA technology.• 4. Measures to give further impetus to R & D in the drug sector: • (a) Newly developed drugs would be put outside price control for a period of 10 years;”
Why relevant

The modified drug policy explicitly promotes R&D in the drug sector and grants regulatory/exemptions (e.g., newly developed drugs outside price control), a pattern that encourages development of novel drug technologies.

How to extend

A student could infer that policy incentives for R&D make it more likely that advanced approaches like nanotechnology-based targeted delivery would be researched and developed domestically, and then check regulatory guidelines for such products.

Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 63
Strength: 4/5
“• (b) Department of Chemicals and Pharmaceuticals to set up inter-ministerial group to decide, within a set time frame, on measures to give further impetus to R & D in the drug sector; and• (c) Ministry of Health and Family Welfare to take suitable steps for the quick clearance of new drug application, especially those developed through indigenous R & D.• 5. The system of price control would be operated through a single list of price-controlled drugs, selected on the basis of transparent and objective criteria as laid down in the modification in drug policy 1986.• 6. In case of basic manufacture, the rate of return would be higher by 4% over the existing rates which are 14% on net worth or 22% on capital employed.• 7.”
Why relevant

Calls for an inter-ministerial group to boost R&D and for quicker clearance of new drug applications indicate institutional mechanisms exist to evaluate and potentially approve novel drug technologies.

How to extend

One could use this to reason that if nanotech drug carriers are developed, there is a procedural pathway for their regulatory assessment and market entry; confirm by examining specific regulatory approval criteria.

Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > PHARMACEUTICAL INDUSTRY > p. 60
Strength: 4/5
“The drugs and pharmaceutical industry has made a phenomenal progress in India during the last four decades. The country now ranks third in terms of volume of production (10% of global share) and 14th largest by value. Indian exports are destined to various countries around the globe including USA, Europe, Japan and Australia (2011- 12). There are five Central Public Sector Undertakings and five joint Sector Undertakings in the pharmaceutical Industry Sector under the administrative control of the Department of Chemicals and Petrochemicals. Besides, there are two wholly-owned subsidiaries. A brief profile of these organisations is given in the following paragraphs.”
Why relevant

The pharmaceutical industry has grown substantially (large production share and export orientation), showing infrastructure and expertise that can support development/manufacture of advanced formulations.

How to extend

A student might combine this industry capacity with knowledge of nanomedicine manufacturing requirements to judge feasibility of producing targeted nanodrugs in the sector.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 9: The Amazing World of Solutes, Solvents, and Solutions > Our scientific heritage > p. 138
Strength: 3/5
“Water has primarily been used as a solvent for the preparation of medicinal formulations in Ayurveda, Siddha, and other traditional systems of medicine in India. Additionally, drug formulations have been prepared using hydro-alcoholic extracts of the herbs. The Indian systems of medicine have also referred to the use of oils, ghee, milk, and other substances as solvents for drug formulations, to help achieve the therapeutic benefits of the drug.”
Why relevant

Discussion of solvents and traditional formulation methods highlights that drug delivery depends on formulation techniques—implying that new formulation technologies (e.g., nanoformulations) are part of the same conceptual space.

How to extend

One could extend this by comparing standard formulation principles to nanocarrier approaches to see how formulation changes can enable targeted delivery.

Indian Economy, Vivek Singh (7th ed. 2023-24) > Chapter 7: Indian Economy after 2014 > 7.7 Production Linked Incentive Scheme (PLIS) > p. 238
Strength: 3/5
“Fact: Indian pharmaceutical industry is the third largest in the world by volume and 14th largest in terms of value. India contributes 3.5% of total drugs and medicines exported globally. Despite these achievements, India is significantly dependent on import of some basic raw materials (from China), viz., bulk drugs and APIs used to produce finished formulations.”
Why relevant

The industry’s dependence on imported raw materials (APIs) shows a supply-chain constraint that could affect adoption or scale-up of specialized technologies.

How to extend

A student could use this to temper expectations: even if nanotech enables targeted delivery technically, supply/dependency issues might affect implementation—check availability of required nano-grade materials.

Statement 2
Does the use of nanotechnology in the health sector contribute significantly to gene therapy?
Origin: Web / Current Affairs Fairness: CA heavy Web-answerable

Web source
Presence: 5/5
"Using nanotechnology that enabled mRNA-based COVID-19 vaccines, a new approach to gene therapy may improve how physicians treat inherited forms of blindness."
Why this source?
  • Explicitly links nanotechnology (lipid nanoparticles) to a new approach for delivering mRNA for gene therapy.
  • Directly states that nanotechnology that enabled mRNA COVID-19 vaccines may improve gene therapy for inherited blindness.
Web source
Presence: 4/5
"Gene therapy, combined with nanotechnology, holds great potential as an innovative approach to tackling numerous severe and untreatable illnesses, namely cancer."
Why this source?
  • States that gene therapy combined with nanotechnology holds great potential for treating severe illnesses, indicating a significant contribution.
  • Specifically mentions demand for innovative carriers and methodologies—implying nanotech-enabled delivery systems for DNA.
Web source
Presence: 3/5
"Nanotechnology has revolutionized the field of drug delivery by providing an effective and targeted delivery of drugs... The application of nanotechnology in drug delivery involves the use of nanoparticles that are designed to carry drugs and deliver them to the desired site of action"
Why this source?
  • Describes how nanotechnology has revolutionized drug delivery by enabling targeted delivery using nanoparticles.
  • Targeted delivery capability is directly relevant to delivering genetic material in gene therapy applications.

Indian Economy, Nitin Singhania .(ed 2nd 2021-22) > Chapter 9: Agriculture > GENETICALLY MODIFIED (GM) CROPS > p. 301
Strength: 5/5
“• According to WHO, Genetically Modified Organisms (GMO) are the plants, animals or microorganisms in which the hereditary material (DNA) is altered in a manner that does not happen normally by mating or potentially regular recombination. It is also known as modern biotechnology/gene technology.• When genetic modification of a plant is performed, foreign gene (transgene) or gene of some other organism is artificially inserted into the plant's own genes. This is gene modification.”
Why relevant

Gives a clear definition of genetic modification/gene technology and describes insertion of foreign genes (gene modification), identifying the technical target that therapies must achieve.

How to extend

A student can combine this with the basic fact that gene therapy requires safe and effective delivery of genetic material and then ask whether nanotechnology offers such delivery platforms.

Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > India's Role in Vaccine Production > p. 39
Strength: 4/5
“India is one of the world's largest vaccine producers. It manufactures vaccines on a massive scale and supplies them to many countries. Indian vaccine companies played a key role during the COVID-19 pandemic and continue to support global health efforts. Dr. Maharaj Kishan Bhan was a well-known Indian doctor and scientist. As Secretary of the Department of Biotechnology, he helped promote science and innovation in India. He played a key role in developing the Rotavirus vaccine, which protects children from diarrhoea. He believed in using research to create affordable healthcare and made a big difference in India's health and biotechnology sectors.”
Why relevant

Describes India's strong vaccine/biotechnology capabilities and leadership in health biotechnology.

How to extend

Use this to infer that a robust biotech sector could adopt or scale complementary technologies (e.g., nanotech-based delivery) to advance gene therapies.

Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > 19. The Biocon Group > p. 110
Strength: 3/5
“This is a big name in the areas of new industries and is considered to be the torchbearer in the biotechnology segment.”
Why relevant

Names Biocon as a torchbearer in the biotechnology segment, indicating presence of advanced biotech industry actors.

How to extend

A student could check whether such firms work on drug-delivery or genetic therapies and whether they partner with nanotech developers to enable gene therapy.

Environment, Shankar IAS Acedemy .(ed 10th) > Chapter 28: International Organisation and Conventions > Cartagena Protocol on Biosafety to the Convention on Biological Diversity > p. 391
Strength: 4/5
“Biosafety refers to the need to protect human health and the environment from the possible adverse effects of the products of modern biotechnology. The Convention clearly recognizes these twin aspects of modern biotechnology. • r. Access to and transfer of technologies • e. Appropriate procedures to enhance the safety of biotechnology technologies.”
Why relevant

Cartagena Protocol excerpt highlights biosafety concerns and procedures for products of modern biotechnology.

How to extend

Combine this with the understanding that new delivery methods (like nanocarriers) raise biosafety/regulatory issues relevant to gene therapy adoption and impact.

Indian Economy, Vivek Singh (7th ed. 2023-24) > Chapter 7: Indian Economy after 2014 > 7.7 Production Linked Incentive Scheme (PLIS) > p. 238
Strength: 3/5
“Fact: Indian pharmaceutical industry is the third largest in the world by volume and 14th largest in terms of value. India contributes 3.5% of total drugs and medicines exported globally. Despite these achievements, India is significantly dependent on import of some basic raw materials (from China), viz., bulk drugs and APIs used to produce finished formulations.”
Why relevant

Notes the scale and limitations of the pharmaceutical industry (large volume production but import dependence for some inputs), implying capacity and gaps in supporting advanced therapies.

How to extend

A student could use this to judge whether national manufacturing and supply-chain capacity would support scaling nanotechnology-enabled gene therapies.

Pattern takeaway: UPSC Science & Tech questions regarding 'Future Applications' follow a permissive logic. If a statement says Technology X 'can' do Y, it is statistically likely to be correct (90%+ probability). Science is open-ended; proving impossibility is hard.
How you should have studied
  1. [THE VERDICT]: Sitter. This is the 'Hello World' of Nanotechnology preparation. If you studied Nanotech, 'Targeted Drug Delivery' is the very first bullet point in any standard material.
  2. [THE CONCEPTUAL TRIGGER]: Syllabus keyword 'Awareness in the fields of IT, Space, Computers, robotics, nano-technology'. Focus specifically on the 'Applications' subheading.
  3. [THE HORIZONTAL EXPANSION]: Don't stop at Health. Memorize applications in: 1) Environment (Nano-remediation, water filters), 2) Agriculture (Nano-urea, precision farming), 3) Energy (Quantum dot solar cells), 4) Electronics (Graphene transistors), 5) Textiles (Silver nanoparticles for anti-odor).
  4. [THE STRATEGIC METACOGNITION]: For every emerging tech (AI, Nano, Biotech, Blockchain), create a 'Sectoral Matrix': List 3 concrete applications for Health, Agriculture, Environment, and Defense. UPSC asks 'What can it do?', not 'How does it work?'.
Concept hooks from this question
📌 Adjacent topic to master
S1
👉 Pharmaceutical R&D policy and incentives
💡 The insight

Government drug policy references describe measures to give further impetus to R&D in the drug sector, which is the policy context for adopting novel technologies such as nanotech.

High-yield for UPSC: understanding policy levers (incentives, foreign investment rules, R&D support) helps evaluate how new health technologies can be promoted or constrained. Links to governance, science & technology, and economy sections. Prepare by studying policy provisions, R&D incentives, and their practical implications for technology adoption.

📚 Reading List :
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 62
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 63
🔗 Anchor: "Does the use of nanotechnology in the health sector enable targeted drug deliver..."
📌 Adjacent topic to master
S1
👉 Scale and capacity of India's pharmaceutical industry
💡 The insight

References report India's ranking by volume/value and export capacity, which determine the country's ability to manufacture and scale advanced drug-delivery technologies.

Important for UPSC answers assessing feasibility of new healthcare technologies — connects industry structure, trade/dependence on imports (APIs), and implementation capacity. Useful for questions on health infrastructure and industrial policy; revise industry statistics, supply-chain vulnerabilities, and policy responses.

📚 Reading List :
  • Indian Economy, Vivek Singh (7th ed. 2023-24) > Chapter 7: Indian Economy after 2014 > 7.7 Production Linked Incentive Scheme (PLIS) > p. 238
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > PHARMACEUTICAL INDUSTRY > p. 60
🔗 Anchor: "Does the use of nanotechnology in the health sector enable targeted drug deliver..."
📌 Adjacent topic to master
S1
👉 Regulatory pathway and price-treatment for new drugs
💡 The insight

Evidence mentions quicker clearance for new drug applications and price/market treatment for newly developed drugs — key for how innovations (e.g., novel delivery systems) reach patients.

Crucial for answering questions on innovation diffusion in health sector: explains how regulatory and pricing frameworks enable or hinder adoption. Integrates with governance, health policy, and pharma regulation topics; study approval processes, pricing rules, and incentives for indigenous R&D.

📚 Reading List :
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 62
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > Drug Policy > p. 63
🔗 Anchor: "Does the use of nanotechnology in the health sector enable targeted drug deliver..."
📌 Adjacent topic to master
S2
👉 Modern biotechnology / gene modification
💡 The insight

Defines gene modification and modern biotechnology, the conceptual foundation for any gene-based interventions such as gene therapy.

High-yield for UPSC as it clarifies what constitutes gene technology vs. conventional breeding; links to ethics, biosafety and policy debates on genetic interventions. Master by understanding definitions, processes (transgene insertion), and policy implications to answer questions on biotechnology regulation and applications.

📚 Reading List :
  • Indian Economy, Nitin Singhania .(ed 2nd 2021-22) > Chapter 9: Agriculture > GENETICALLY MODIFIED (GM) CROPS > p. 301
🔗 Anchor: "Does the use of nanotechnology in the health sector contribute significantly to ..."
📌 Adjacent topic to master
S2
👉 Biosafety and international regulation (Cartagena Protocol)
💡 The insight

Frames the safety, environmental and regulatory concerns around modern biotechnology products that would include gene therapies.

Important for GS Paper topics on environment, international agreements and policy. Questions often probe regulatory frameworks and risk management for biotech advances; study the Protocol's aims, biosafety principles and national implementation measures.

📚 Reading List :
  • Environment, Shankar IAS Acedemy .(ed 10th) > Chapter 28: International Organisation and Conventions > Cartagena Protocol on Biosafety to the Convention on Biological Diversity > p. 391
🔗 Anchor: "Does the use of nanotechnology in the health sector contribute significantly to ..."
📌 Adjacent topic to master
S2
👉 India's biotechnology and vaccine production capacity
💡 The insight

Illustrates India's industrial and institutional capacity in biotech and health-sector production, relevant when assessing adoption or scaling of advanced health technologies.

Useful for answers on India's health infrastructure, biotech industry and manufacturing policy (e.g., PLI, major firms). UPSC questions may ask about nation's capacity to adopt new medical technologies; prepare by linking industry facts, major firms and policy supports.

📚 Reading List :
  • Science ,Class VIII . NCERT(Revised ed 2025) > Chapter 3: Health: The Ultimate Treasure > India's Role in Vaccine Production > p. 39
  • Geography of India ,Majid Husain, (McGrawHill 9th ed.) > Chapter 11: Industries > 19. The Biocon Group > p. 110
  • Indian Economy, Vivek Singh (7th ed. 2023-24) > Chapter 7: Indian Economy after 2014 > 7.7 Production Linked Incentive Scheme (PLIS) > p. 238
🔗 Anchor: "Does the use of nanotechnology in the health sector contribute significantly to ..."
🌑 The Hidden Trap

Since they asked about Drug Delivery (Liposomes/Dendrimers), the next logical question is on 'Theranostics' (Therapy + Diagnostics combined) or specific materials like 'Quantum Dots' (used for medical imaging) and 'Gold Nanoshells' (cancer thermal therapy).

⚡ Elimination Cheat Code

The 'Possibility Heuristic': In Science & Tech, statements using modal verbs like 'can', 'may', 'possible', or 'contribute to' are almost always True. Unless the statement contains an extreme restrictor (e.g., 'can ONLY be done by...'), mark it correct. The examiner cannot easily prove that a nascent technology *cannot* do something.

🔗 Mains Connection

Bridge to GS-3 Agriculture & Economy: Connect Nanotech in health to 'Nano-Urea' in Agriculture. Just as nanotech reduces drug dosage/side-effects in humans, Nano-Urea reduces fertilizer runoff and subsidy burden in the economy. It's the same principle of 'Targeted Delivery' applied to plants.

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