Which one among the following is not correct about Downs syndrome?

Down syndrome, also known as Trisomy 21, is a common chromosomal genetic disorder [1]. It is characterized by a range of clinical features, including intellectual disability (mental retardation), which affects nearly all individuals with the condition, typically in the mild to moderate range. Physical manifestations often include macroglossia (an enlarged tongue), which may be fissured or furrowed, and is frequently associated with a protruding tongue and an open mouth. While individuals with Down syndrome are at a higher risk for certain age-related conditions like Alzheimer's disease, 'early ageing' is not a standard diagnostic clinical feature of the syndrome itself in the same way that genetic factors, mental retardation, and specific facial/oral characteristics are. Therefore, option 2 is the most appropriate choice for the statement that is not correct regarding the primary clinical description of Down syndrome.

Sources

1. [1] https://www.sciencedirect.com/topics/medicine-and-dentistry/faciogenital-dysplasia